TY - JOUR

T1 - Collagen turnover after tibial fractures

AU - Joerring, S

AU - Krogsgaard, M

AU - Wilbek, H

AU - Jensen, L T

PY - 1994

Y1 - 1994

N2 - Collagen turnover after tibial fractures was examined in 16 patients with fracture of the tibial diaphysis and in 8 patients with fracture in the tibial condyle area by measuring sequential changes in serological markers of turnover of types I and III collagen for up to 26 weeks after fracture. The markers were the carboxy-terminal extension peptide of type I procollagen (PICP), the amino-terminal extension peptide of type III procollagen (PIIINP), and the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP). The latter is a new serum marker of degradation of type I collagen. A group comparison showed characteristic sequential changes in the turnover of types I and III collagen in fractures of the tibial diaphysis and tibial condyles. The turnover of type III collagen reached a maximum after 2 weeks in both groups. The synthesis of type I collagen reached a maximum after 2 weeks in the diaphyseal fractures and after 6 weeks in the condylar fractures. The degradation of type I collagen increased after 4 days and reached a maximum at 2 weeks in both groups. The interindividual variation was wide. On a group basis, the turnover of types I and III collagen had levelled of within 26 weeks, although some patients had clearly elevated parameters at the end of the observational period. We suggest that delayed healing of tibial diaphyseal fractures is accompanied by an early increase in the turnover of types I and III collagen.

AB - Collagen turnover after tibial fractures was examined in 16 patients with fracture of the tibial diaphysis and in 8 patients with fracture in the tibial condyle area by measuring sequential changes in serological markers of turnover of types I and III collagen for up to 26 weeks after fracture. The markers were the carboxy-terminal extension peptide of type I procollagen (PICP), the amino-terminal extension peptide of type III procollagen (PIIINP), and the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP). The latter is a new serum marker of degradation of type I collagen. A group comparison showed characteristic sequential changes in the turnover of types I and III collagen in fractures of the tibial diaphysis and tibial condyles. The turnover of type III collagen reached a maximum after 2 weeks in both groups. The synthesis of type I collagen reached a maximum after 2 weeks in the diaphyseal fractures and after 6 weeks in the condylar fractures. The degradation of type I collagen increased after 4 days and reached a maximum at 2 weeks in both groups. The interindividual variation was wide. On a group basis, the turnover of types I and III collagen had levelled of within 26 weeks, although some patients had clearly elevated parameters at the end of the observational period. We suggest that delayed healing of tibial diaphyseal fractures is accompanied by an early increase in the turnover of types I and III collagen.

KW - Adult

KW - Aged

KW - Biomarkers

KW - Bony Callus

KW - Collagen

KW - Collagen Type I

KW - Diaphyses

KW - Female

KW - Fracture Healing

KW - Humans

KW - Male

KW - Middle Aged

KW - Peptide Fragments

KW - Peptides

KW - Procollagen

KW - Tibial Fractures

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/BF00426183

DO - 10.1007/BF00426183

M3 - Journal article

C2 - 7833212

VL - 113

SP - 334

EP - 336

JO - Archives of Orthopaedic and Trauma Surgery

JF - Archives of Orthopaedic and Trauma Surgery

SN - 0936-8051

IS - 6

ER -