Collagen Homeostasis and Metabolism
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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Collagen Homeostasis and Metabolism. / Magnusson, S Peter; Heinemeier, Katja M; Kjaer, Michael.
Metabolic Influences on Risk for Tendon Disorders. Bind 920 Springer, 2016. s. 11-25 (Advances in Experimental Medicine and Biology, Bind 920).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Collagen Homeostasis and Metabolism
AU - Magnusson, S Peter
AU - Heinemeier, Katja M
AU - Kjaer, Michael
PY - 2016
Y1 - 2016
N2 - The musculoskeletal system and its collagen rich tissue is important for ensuring architecture of skeletal muscle, energy storage in tendon and ligaments, joint surface protection, and for ensuring the transfer of muscular forces into resulting limb movement. Structure of tendon is stable and the metabolic activity is low, but mechanical loading and subsequent mechanotransduction and molecular anabolic signaling can result in some adaptation of the tendon especially during youth and adolescence. Within short time, tendon will get stiffer with training and lack of mechanical tissue loading through inactivity or immobilization of the human body will conversely result in a dramatic loss in tendon stiffness and collagen synthesis. This illustrates the importance of regular mechanical load in order to preserve the stabilizing role of the connective tissue for the overall function of the musculoskeletal system in both daily activity and exercise. Adaptive responses may vary along the tendon, and differ between mid-substance and insertional areas of the tendon.
AB - The musculoskeletal system and its collagen rich tissue is important for ensuring architecture of skeletal muscle, energy storage in tendon and ligaments, joint surface protection, and for ensuring the transfer of muscular forces into resulting limb movement. Structure of tendon is stable and the metabolic activity is low, but mechanical loading and subsequent mechanotransduction and molecular anabolic signaling can result in some adaptation of the tendon especially during youth and adolescence. Within short time, tendon will get stiffer with training and lack of mechanical tissue loading through inactivity or immobilization of the human body will conversely result in a dramatic loss in tendon stiffness and collagen synthesis. This illustrates the importance of regular mechanical load in order to preserve the stabilizing role of the connective tissue for the overall function of the musculoskeletal system in both daily activity and exercise. Adaptive responses may vary along the tendon, and differ between mid-substance and insertional areas of the tendon.
KW - Journal Article
U2 - 10.1007/978-3-319-33943-6_2
DO - 10.1007/978-3-319-33943-6_2
M3 - Book chapter
C2 - 27535245
SN - 978-3-319-33941-2
VL - 920
T3 - Advances in Experimental Medicine and Biology
SP - 11
EP - 25
BT - Metabolic Influences on Risk for Tendon Disorders
PB - Springer
ER -
ID: 178578094