Cohort profile: The COPENHAGEN Minipuberty Study—A longitudinal prospective cohort of healthy full‐term infants and their parents
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Cohort profile : The COPENHAGEN Minipuberty Study—A longitudinal prospective cohort of healthy full‐term infants and their parents. / Busch, Alexander Siegfried; Ljubicic, Marie Lindhardt; Upners, Emmie N.; Fischer, Margit Bistrup; Kolby, Nanna; Eckert‐lind, Camilla; Jespersen, Kirstine; Andersson, Anna‐maria; Frederiksen, Hanne; Johannsen, Trine Holm; Hegaard, Hanne Kristine; Sharif, Heidi; Hagen, Casper P.; Juul, Anders.
I: Paediatric and Perinatal Epidemiology, Bind 35, Nr. 5, 01.09.2021, s. 601-611.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cohort profile
T2 - The COPENHAGEN Minipuberty Study—A longitudinal prospective cohort of healthy full‐term infants and their parents
AU - Busch, Alexander Siegfried
AU - Ljubicic, Marie Lindhardt
AU - Upners, Emmie N.
AU - Fischer, Margit Bistrup
AU - Kolby, Nanna
AU - Eckert‐lind, Camilla
AU - Jespersen, Kirstine
AU - Andersson, Anna‐maria
AU - Frederiksen, Hanne
AU - Johannsen, Trine Holm
AU - Hegaard, Hanne Kristine
AU - Sharif, Heidi
AU - Hagen, Casper P.
AU - Juul, Anders
PY - 2021/9/1
Y1 - 2021/9/1
N2 - BackgroundThe hypothalamic-pituitary-gonadal (HPG) axis governs sexual maturation and reproductive function in humans. In early postnatal life, it is transiently active during which circulating sex steroids reach adult levels. While this so-called minipuberty represents a universal phenomenon in infants of both sexes, its role for early maturation and growth remains incompletely understood.ObjectivesTo provide normative data on auxology as well as serum and urinary hormone levels in healthy, full-term infants throughout the first year of life and to investigate associations of postnatal HPG axis dynamics as well as hormonal, genetic and environmental exposures with early genital development and growth.PopulationHealthy, Danish, full-term, singleton newborns including their parents.DesignSingle-centre, prospective, observational longitudinal pregnancy and birth cohort.MethodsNewborns were followed with six repeated clinical examinations during a one-year follow-up period. An umbilical cord blood sample was drawn at birth. At each visit, infants underwent a clinical examination focusing on auxology and genital development. Further, blood (serum, plasma, DNA) and urine samples were collected at each visit. Mothers and fathers underwent a clinical examination and provided blood samples prior to and after birth. A subset of parents provided urine samples and breast milk samples. Pregnancy and obstetrical outcomes, and detailed parental questionnaires were compiled.Preliminary resultsBetween August 2016 and August 2018, 2481 women with singleton pregnancies were invited to participate of which 298, including their partners, were enrolled (12.0%). A total of 268 healthy, full-term newborns born appropriate for gestational age (AGA) were included at birth, 233 newborns participated in the postnatal follow-up period and 186 completed the one-year follow-up period (9.4% and 7.5%, respectively).ConclusionThe COPENHAGEN Minipuberty Study provides detailed, longitudinal data on early genital development and growth including hormonal and genetic profiles and environmental exposure in healthy infants including additional data in their parents.
AB - BackgroundThe hypothalamic-pituitary-gonadal (HPG) axis governs sexual maturation and reproductive function in humans. In early postnatal life, it is transiently active during which circulating sex steroids reach adult levels. While this so-called minipuberty represents a universal phenomenon in infants of both sexes, its role for early maturation and growth remains incompletely understood.ObjectivesTo provide normative data on auxology as well as serum and urinary hormone levels in healthy, full-term infants throughout the first year of life and to investigate associations of postnatal HPG axis dynamics as well as hormonal, genetic and environmental exposures with early genital development and growth.PopulationHealthy, Danish, full-term, singleton newborns including their parents.DesignSingle-centre, prospective, observational longitudinal pregnancy and birth cohort.MethodsNewborns were followed with six repeated clinical examinations during a one-year follow-up period. An umbilical cord blood sample was drawn at birth. At each visit, infants underwent a clinical examination focusing on auxology and genital development. Further, blood (serum, plasma, DNA) and urine samples were collected at each visit. Mothers and fathers underwent a clinical examination and provided blood samples prior to and after birth. A subset of parents provided urine samples and breast milk samples. Pregnancy and obstetrical outcomes, and detailed parental questionnaires were compiled.Preliminary resultsBetween August 2016 and August 2018, 2481 women with singleton pregnancies were invited to participate of which 298, including their partners, were enrolled (12.0%). A total of 268 healthy, full-term newborns born appropriate for gestational age (AGA) were included at birth, 233 newborns participated in the postnatal follow-up period and 186 completed the one-year follow-up period (9.4% and 7.5%, respectively).ConclusionThe COPENHAGEN Minipuberty Study provides detailed, longitudinal data on early genital development and growth including hormonal and genetic profiles and environmental exposure in healthy infants including additional data in their parents.
U2 - 10.1111/ppe.12777
DO - 10.1111/ppe.12777
M3 - Journal article
C2 - 34156716
VL - 35
SP - 601
EP - 611
JO - Paediatric and Perinatal Epidemiology
JF - Paediatric and Perinatal Epidemiology
SN - 0269-5022
IS - 5
ER -
ID: 280615619