Cognitive impairment and psychopathology in sudden out-of-hospital cardiac arrest survivors: Results from the REVIVAL cohort study
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Cognitive impairment and psychopathology in sudden out-of-hospital cardiac arrest survivors : Results from the REVIVAL cohort study. / Wagner, Mette Kirstine; Berg, Selina Kikkenborg; Hassager, Christian; Borregaard, Britt; Rasmussen, Trine Bernholdt; Ekholm, Ola; Stenbæk, Dea Siggaard.
I: Resuscitation, Bind 192, 109984, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cognitive impairment and psychopathology in sudden out-of-hospital cardiac arrest survivors
T2 - Results from the REVIVAL cohort study
AU - Wagner, Mette Kirstine
AU - Berg, Selina Kikkenborg
AU - Hassager, Christian
AU - Borregaard, Britt
AU - Rasmussen, Trine Bernholdt
AU - Ekholm, Ola
AU - Stenbæk, Dea Siggaard
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Aim: To investigate cognitive impairment and psychopathology in out-of-hospital cardiac arrest (OHCA) survivors using a screening procedure during hospitalisation and examine the evolution of these parameters at three-month follow-up. Methods: This multicentre cohort study screened for cognitive impairment using the Montreal Cognitive Assessment (MoCA), for symptoms of anxiety, depression and traumatic distress using the Hospital Anxiety and Depression Scale (HADS) and the Impact of Event Scale–revised (IES-R) during hospitalisation. At three-month follow-up, we evaluated cognitive impairment with a neuropsychological test battery and symptoms of psychopathology were re-assessed using HADS and IES-R. Logistic regression models were applied to examine associations between screening results and outcomes. Results: This study included 297 OHCA survivors. During hospitalisation, 65% presented with cognitive impairment, 25% reported symptoms of anxiety, 20% symptoms of depression and 21% symptoms of traumatic distress. At follow-up, 53% reported cognitive impairment, 17% symptoms of anxiety, 15% symptoms of depression and 19% symptoms of traumatic distress. Cognitive impairment during hospitalisation was associated with higher odds (OR (95% CI) 2.55 (1.36–4.75), p = .02) of an unfavorable cognitive outcome at follow-up, and symptoms of psychopathology during hospitalisation were associated with higher odds of psychopathology at follow-up across all three symptom groups; anxiety (6.70 (2.40–18.72), p < .001), depression (4.69 (1.69–13.02), p < .001) and traumatic distress (7.07 (2.67–18.73), p < .001). Conclusion: OHCA survivors exhibited both cognitive impairment and symptoms of psychopathology during hospitalisation comparable to previous studies, which were associated with unfavorable mental health outcomes at three-month follow-up.
AB - Aim: To investigate cognitive impairment and psychopathology in out-of-hospital cardiac arrest (OHCA) survivors using a screening procedure during hospitalisation and examine the evolution of these parameters at three-month follow-up. Methods: This multicentre cohort study screened for cognitive impairment using the Montreal Cognitive Assessment (MoCA), for symptoms of anxiety, depression and traumatic distress using the Hospital Anxiety and Depression Scale (HADS) and the Impact of Event Scale–revised (IES-R) during hospitalisation. At three-month follow-up, we evaluated cognitive impairment with a neuropsychological test battery and symptoms of psychopathology were re-assessed using HADS and IES-R. Logistic regression models were applied to examine associations between screening results and outcomes. Results: This study included 297 OHCA survivors. During hospitalisation, 65% presented with cognitive impairment, 25% reported symptoms of anxiety, 20% symptoms of depression and 21% symptoms of traumatic distress. At follow-up, 53% reported cognitive impairment, 17% symptoms of anxiety, 15% symptoms of depression and 19% symptoms of traumatic distress. Cognitive impairment during hospitalisation was associated with higher odds (OR (95% CI) 2.55 (1.36–4.75), p = .02) of an unfavorable cognitive outcome at follow-up, and symptoms of psychopathology during hospitalisation were associated with higher odds of psychopathology at follow-up across all three symptom groups; anxiety (6.70 (2.40–18.72), p < .001), depression (4.69 (1.69–13.02), p < .001) and traumatic distress (7.07 (2.67–18.73), p < .001). Conclusion: OHCA survivors exhibited both cognitive impairment and symptoms of psychopathology during hospitalisation comparable to previous studies, which were associated with unfavorable mental health outcomes at three-month follow-up.
KW - Mild cognitive impairment
KW - Montreal Cognitive Assessment
KW - Psychopathology
KW - Resuscitation
KW - Screening tool
U2 - 10.1016/j.resuscitation.2023.109984
DO - 10.1016/j.resuscitation.2023.109984
M3 - Journal article
C2 - 37797716
AN - SCOPUS:85173873024
VL - 192
JO - Resuscitation
JF - Resuscitation
SN - 0300-9572
M1 - 109984
ER -
ID: 371028542