Cognitive effects of six months of treatment with quetiapine in antipsychotic-naïve first-episode schizophrenia
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Cognitive effects of six months of treatment with quetiapine in antipsychotic-naïve first-episode schizophrenia. / Andersen, Rune; Fagerlund, Birgitte; Rasmussen, Hans; Ebdrup, Bjorn H; Aggernaes, Bodil; Gade, Anders; Oranje, Bob; Glenthøj, Birte Yding.
I: Psychiatry Research, Bind 187, Nr. 1-2, 15.05.2011, s. 49-54.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cognitive effects of six months of treatment with quetiapine in antipsychotic-naïve first-episode schizophrenia
AU - Andersen, Rune
AU - Fagerlund, Birgitte
AU - Rasmussen, Hans
AU - Ebdrup, Bjorn H
AU - Aggernaes, Bodil
AU - Gade, Anders
AU - Oranje, Bob
AU - Glenthøj, Birte Yding
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2011/5/15
Y1 - 2011/5/15
N2 - Effects of quetiapine on cognition were assessed in a group of first-episode antipsychotic-naïve patients with schizophrenia (N=24). A comprehensive battery of neuropsychological tests was administered at baseline and after 6months of treatment with quetiapine. In order to examine retest effects, a matched healthy control group (N=24) was also tested at baseline and after 6months. Only few differential changes were observed between patients and healthy controls. Of 8 cognitive domains examined, only significant changes in executive function suggested possible ameliorating effects of quetiapine. Patients also improved on speed of processing; however, this was parallel to the retest effects found in healthy controls. When covaried for differences at baseline, patients showed smaller improvements in speed of processing than the retest effects found in controls, as well as a lack of retest effects on sustained attention and working memory that were found in healthy controls. The main result of the study is that there was very little evidence of efficacy of quetiapine on cognition. The study also indicated a lack of normal retest effects in patients compared to controls.
AB - Effects of quetiapine on cognition were assessed in a group of first-episode antipsychotic-naïve patients with schizophrenia (N=24). A comprehensive battery of neuropsychological tests was administered at baseline and after 6months of treatment with quetiapine. In order to examine retest effects, a matched healthy control group (N=24) was also tested at baseline and after 6months. Only few differential changes were observed between patients and healthy controls. Of 8 cognitive domains examined, only significant changes in executive function suggested possible ameliorating effects of quetiapine. Patients also improved on speed of processing; however, this was parallel to the retest effects found in healthy controls. When covaried for differences at baseline, patients showed smaller improvements in speed of processing than the retest effects found in controls, as well as a lack of retest effects on sustained attention and working memory that were found in healthy controls. The main result of the study is that there was very little evidence of efficacy of quetiapine on cognition. The study also indicated a lack of normal retest effects in patients compared to controls.
M3 - Journal article
VL - 187
SP - 49
EP - 54
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1-2
ER -
ID: 34046064