Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy
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Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy. / Bourgeois-Vionnet, Julie; Ryvlin, Philippe; Elsensohn, Mad Hélénie; Michel, Véronique; Valton, Luc; Derambure, Philippe; Frazzini, Valerio; Hirsch, Edouard; Maillard, Louis; Bartolomei, Fabrice; Biberon, Julien; Petit, Jerôme; Biraben, Arnaud; Crespel, Arielle; Thomas, Pierre; Lemesle-Martin, Martine; Convers, Philippe; Leclercq, Mathilde; Boulogne, Sébastien; Roy, Pascal; Rheims, Sylvain.
I: Epilepsy and Behavior, Bind 126, 108486, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy
AU - Bourgeois-Vionnet, Julie
AU - Ryvlin, Philippe
AU - Elsensohn, Mad Hélénie
AU - Michel, Véronique
AU - Valton, Luc
AU - Derambure, Philippe
AU - Frazzini, Valerio
AU - Hirsch, Edouard
AU - Maillard, Louis
AU - Bartolomei, Fabrice
AU - Biberon, Julien
AU - Petit, Jerôme
AU - Biraben, Arnaud
AU - Crespel, Arielle
AU - Thomas, Pierre
AU - Lemesle-Martin, Martine
AU - Convers, Philippe
AU - Leclercq, Mathilde
AU - Boulogne, Sébastien
AU - Roy, Pascal
AU - Rheims, Sylvain
N1 - Publisher Copyright: © 2021 Elsevier Inc.
PY - 2022
Y1 - 2022
N2 - Objective: To assess the relation between coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy. Methods: Cross-sectional analysis of data collected in the SAVE study, which included patients with drug-resistant focal epilepsy during long-term EEG monitoring. Patients in whom both coffee consumption and data about seizure frequency, including focal to bilateral tonic-clonic seizures (FBTCS), were available were selected. Coffee consumption was collected using a standardized self-report questionnaire and classified into four groups: none, rare (from less than 1 cup/week to up 3 cups/week), moderate (from 4 cups/week to 3 cups/day), and high (more than 4 cups/day). Results: Six hundred and nineteen patients were included. There was no relation between coffee consumption and total seizure frequency (p = 0.902). In contrast, the number of FBTCS reported over the past year was significantly associated with usual coffee consumption (p = 0.029). Specifically, number of FBCTS in patients who reported moderate coffee consumption was lower than in others. In comparison with patients with moderate coffee consumption, the odds ratio (95%CI) for reporting at least 1 FBTCS per year was 1.6 (1.03–2.49) in patients who never take coffee, 1.62 (1.02–2.57) in those with rare consumption and 2.05 (1.24–3.4) in those with high consumption. Multiple ordinal logistic regression showed a trend toward an association between coffee consumption and number of FBTCS (p = 0.08). Conclusions and relevance: Our data suggest that effect of coffee consumption on seizures might depend on dose with potential benefits on FBTCS frequency at moderate doses. These results will have to be confirmed by prospective studies.
AB - Objective: To assess the relation between coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy. Methods: Cross-sectional analysis of data collected in the SAVE study, which included patients with drug-resistant focal epilepsy during long-term EEG monitoring. Patients in whom both coffee consumption and data about seizure frequency, including focal to bilateral tonic-clonic seizures (FBTCS), were available were selected. Coffee consumption was collected using a standardized self-report questionnaire and classified into four groups: none, rare (from less than 1 cup/week to up 3 cups/week), moderate (from 4 cups/week to 3 cups/day), and high (more than 4 cups/day). Results: Six hundred and nineteen patients were included. There was no relation between coffee consumption and total seizure frequency (p = 0.902). In contrast, the number of FBTCS reported over the past year was significantly associated with usual coffee consumption (p = 0.029). Specifically, number of FBCTS in patients who reported moderate coffee consumption was lower than in others. In comparison with patients with moderate coffee consumption, the odds ratio (95%CI) for reporting at least 1 FBTCS per year was 1.6 (1.03–2.49) in patients who never take coffee, 1.62 (1.02–2.57) in those with rare consumption and 2.05 (1.24–3.4) in those with high consumption. Multiple ordinal logistic regression showed a trend toward an association between coffee consumption and number of FBTCS (p = 0.08). Conclusions and relevance: Our data suggest that effect of coffee consumption on seizures might depend on dose with potential benefits on FBTCS frequency at moderate doses. These results will have to be confirmed by prospective studies.
KW - Caffeine
KW - Epilepsy
KW - Generalized seizures
KW - Seizures
U2 - 10.1016/j.yebeh.2021.108486
DO - 10.1016/j.yebeh.2021.108486
M3 - Journal article
C2 - 34929474
AN - SCOPUS:85121209760
VL - 126
JO - Epilepsy & Behavior
JF - Epilepsy & Behavior
SN - 1525-5050
M1 - 108486
ER -
ID: 313777576