TY - JOUR

T1 - Coeliac disease in children

T2 - a social epidemiological study in Sweden

AU - Clinical Sciences, Malmö, Lund University, Department

AU - Björck, Sara

AU - Lynch, Kristian F

AU - Ohlsson, Henrik

AU - Agardh, Daniel

AU - Merlo, Juan

N1 - © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

PY - 2012/2

Y1 - 2012/2

N2 - AIM: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two.METHODS: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792,401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics.RESULTS: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation ≈ 10%) that was not explained by individual characteristics.CONCLUSIONS: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.

AB - AIM: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two.METHODS: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792,401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics.RESULTS: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation ≈ 10%) that was not explained by individual characteristics.CONCLUSIONS: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.

KW - Celiac Disease/epidemiology

KW - Child, Preschool

KW - Data Collection

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Prospective Studies

KW - Registries

KW - Residence Characteristics/statistics & numerical data

KW - Risk Factors

KW - Sex Distribution

KW - Social Class

KW - Sweden/epidemiology

U2 - 10.1111/j.1651-2227.2011.02434.x

DO - 10.1111/j.1651-2227.2011.02434.x

M3 - Journal article

C2 - 21824189

VL - 101

SP - 185

EP - 191

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 2

ER -