Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study
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Coagulation Status in Hidradenitis Suppurativa : A Danish Population- and Hospital-Based Cross-Sectional Study. / Miller, Iben Marie; Johansen, Maria Egede; Mogensen, Ulla B; Zarchi, Kian; Ellervik, Christina; Jemec, Gregor B E.
I: Dermatology, Bind 231, Nr. 2, 07.2015, s. 119-26.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Coagulation Status in Hidradenitis Suppurativa
T2 - A Danish Population- and Hospital-Based Cross-Sectional Study
AU - Miller, Iben Marie
AU - Johansen, Maria Egede
AU - Mogensen, Ulla B
AU - Zarchi, Kian
AU - Ellervik, Christina
AU - Jemec, Gregor B E
PY - 2015/7
Y1 - 2015/7
N2 - BACKGROUND: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status.OBJECTIVE: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state.METHODS: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]).RESULTS: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432).CONCLUSION: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.
AB - BACKGROUND: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status.OBJECTIVE: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state.METHODS: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]).RESULTS: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432).CONCLUSION: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Blood Coagulation
KW - Case-Control Studies
KW - Cross-Sectional Studies
KW - Denmark
KW - Female
KW - Hidradenitis Suppurativa
KW - Hospitals
KW - Humans
KW - International Normalized Ratio
KW - Male
KW - Mean Platelet Volume
KW - Middle Aged
KW - Partial Thromboplastin Time
KW - Platelet Count
KW - Severity of Illness Index
KW - Thrombocytopenia
KW - Thrombophilia
KW - Young Adult
U2 - 10.1159/000430910
DO - 10.1159/000430910
M3 - Journal article
C2 - 26138620
VL - 231
SP - 119
EP - 126
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 2
ER -
ID: 162092870