TY - JOUR

T1 - Coagulation Status in Hidradenitis Suppurativa

T2 - A Danish Population- and Hospital-Based Cross-Sectional Study

AU - Miller, Iben Marie

AU - Johansen, Maria Egede

AU - Mogensen, Ulla B

AU - Zarchi, Kian

AU - Ellervik, Christina

AU - Jemec, Gregor B E

PY - 2015/7

Y1 - 2015/7

N2 - BACKGROUND: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status.OBJECTIVE: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state.METHODS: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]).RESULTS: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432).CONCLUSION: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.

AB - BACKGROUND: Chronic inflammatory diseases other than hidradenitis suppurativa (HS) have been associated with prothrombotic/hypercoagulable status.OBJECTIVE: To investigate a possible association between the chronic inflammatory skin disease HS and prothrombotic/hypercoagulable state.METHODS: We performed a hospital- and population-based cross-sectional study investigating the coagulation status (thrombocytes, mean platelet volume [MPV], international normalized ratio [INR] and activated partial thromboplastin time [APTT]).RESULTS: 32 hospital HS subjects, 430 population HS subjects and 20,780 population non-HS control subjects were identified. The adjusted analyses showed no differences in the levels of thrombocytes, MPV, INR or APTT between the HS groups (hospital HS group, population HS group) when compared to controls (p = 0.089, p = 0.3078; p = 0.5499, p = 0.0659; p = 0.0932; p = 0.3432).CONCLUSION: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Blood Coagulation

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Denmark

KW - Female

KW - Hidradenitis Suppurativa

KW - Hospitals

KW - Humans

KW - International Normalized Ratio

KW - Male

KW - Mean Platelet Volume

KW - Middle Aged

KW - Partial Thromboplastin Time

KW - Platelet Count

KW - Severity of Illness Index

KW - Thrombocytopenia

KW - Thrombophilia

KW - Young Adult

U2 - 10.1159/000430910

DO - 10.1159/000430910

M3 - Journal article

C2 - 26138620

VL - 231

SP - 119

EP - 126

JO - Dermatology

JF - Dermatology

SN - 1018-8665

IS - 2

ER -