Clustering on Membranes: Fluctuations and More
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Clustering on Membranes : Fluctuations and More. / Johannes, Ludger; Pezeshkian, Weria; Ipsen, John H.; Shillcock, Julian C.
I: Trends in Cell Biology, Bind 28, Nr. 5, 05.2018, s. 405-415.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Clustering on Membranes
T2 - Fluctuations and More
AU - Johannes, Ludger
AU - Pezeshkian, Weria
AU - Ipsen, John H.
AU - Shillcock, Julian C.
PY - 2018/5
Y1 - 2018/5
N2 - Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocytosis. Attractive forces that originate in perturbations of the membrane's physical properties contribute to this clustering, in addition to direct protein-protein interactions. However, these membrane-mediated forces have not all been equally considered, despite their importance. In this review, we describe how line tension, lipid depletion, and membrane curvature contribute to membrane-mediated clustering. Additional attractive forces that arise from protein-induced perturbation of a membrane's fluctuations are also described. This review aims to provide a survey of the current understanding of membrane-mediated clustering and how this supports precise biological functions.
AB - Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocytosis. Attractive forces that originate in perturbations of the membrane's physical properties contribute to this clustering, in addition to direct protein-protein interactions. However, these membrane-mediated forces have not all been equally considered, despite their importance. In this review, we describe how line tension, lipid depletion, and membrane curvature contribute to membrane-mediated clustering. Additional attractive forces that arise from protein-induced perturbation of a membrane's fluctuations are also described. This review aims to provide a survey of the current understanding of membrane-mediated clustering and how this supports precise biological functions.
KW - CURVATURE-MEDIATED INTERACTIONS
KW - CELL-MEMBRANE
KW - PLASMA-MEMBRANES
KW - BIOLOGICAL-MEMBRANES
KW - ANCHORED PROTEINS
KW - PHASE-SEPARATION
KW - LIPID-BILAYERS
KW - INDUCED FORCES
KW - ORGANIZATION
KW - RAFTS
U2 - 10.1016/j.tcb.2018.01.009
DO - 10.1016/j.tcb.2018.01.009
M3 - Review
VL - 28
SP - 405
EP - 415
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 5
ER -
ID: 316865659