Clinicopathologic characteristics of Burkitt lymphoma of the head and neck in a non-endemic region—a Danish nationwide study
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Clinicopathologic characteristics of Burkitt lymphoma of the head and neck in a non-endemic region—a Danish nationwide study. / Dupont Harwood, Cecilie; Eriksen, Patrick René Gerhard; Clasen-Linde, Erik; Jensen, Jakob Schmidt; Asdahl, Peter; Rasmussen, Malin; Hjalgrim, Lisa Lyngsie; Heegaard, Steffen; von Buchwald, Christian.
I: Acta Oto-Laryngologica, Bind 141, Nr. 8, 2021, s. 812-819.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Clinicopathologic characteristics of Burkitt lymphoma of the head and neck in a non-endemic region—a Danish nationwide study
AU - Dupont Harwood, Cecilie
AU - Eriksen, Patrick René Gerhard
AU - Clasen-Linde, Erik
AU - Jensen, Jakob Schmidt
AU - Asdahl, Peter
AU - Rasmussen, Malin
AU - Hjalgrim, Lisa Lyngsie
AU - Heegaard, Steffen
AU - von Buchwald, Christian
N1 - Publisher Copyright: © 2021 Acta Oto-Laryngologica AB (Ltd).
PY - 2021
Y1 - 2021
N2 - Background: Burkitt lymphoma rarely presents in head and neck (H&N) in Western countries. Aims/objectives: We aimed to characterise clinicopathological features of H&N Burkitt lymphoma in Denmark representing a non-endemic region. Material and methods: Clinical records were reviewed for a nationwide cohort of patients diagnosed with H&N Burkitt lymphoma in Denmark between 1980 and 2018. The diagnosis was histologically validated. Results: Thirty-four patients with H&N Burkitt lymphoma (highest incidence in age group 0–9 years, male-to-female ratio 4.7:1) were included. Thirty-three lymphomas (97%) were extranodal. The tumour was visible at the clinical examination in 81% (n = 22) of the cases. The palatine tonsils were the most frequent location (n = 13, 38%) and 52% (n = 17) of the patients were diagnosed in advanced stage. Lymphoma was the tentative clinical diagnosis in 23% of the cases. The 5-year overall- and disease-specific survival was 78% and 81%, respectively. Conclusions: Due to the rarity of Burkitt lymphoma of the H&N, there is a high risk of clinical misdiagnosis. Our findings suggest which symptoms and clinical presentations to be aware of in the diagnostics work up that could lead to the diagnosis of Burkitt lymphoma.
AB - Background: Burkitt lymphoma rarely presents in head and neck (H&N) in Western countries. Aims/objectives: We aimed to characterise clinicopathological features of H&N Burkitt lymphoma in Denmark representing a non-endemic region. Material and methods: Clinical records were reviewed for a nationwide cohort of patients diagnosed with H&N Burkitt lymphoma in Denmark between 1980 and 2018. The diagnosis was histologically validated. Results: Thirty-four patients with H&N Burkitt lymphoma (highest incidence in age group 0–9 years, male-to-female ratio 4.7:1) were included. Thirty-three lymphomas (97%) were extranodal. The tumour was visible at the clinical examination in 81% (n = 22) of the cases. The palatine tonsils were the most frequent location (n = 13, 38%) and 52% (n = 17) of the patients were diagnosed in advanced stage. Lymphoma was the tentative clinical diagnosis in 23% of the cases. The 5-year overall- and disease-specific survival was 78% and 81%, respectively. Conclusions: Due to the rarity of Burkitt lymphoma of the H&N, there is a high risk of clinical misdiagnosis. Our findings suggest which symptoms and clinical presentations to be aware of in the diagnostics work up that could lead to the diagnosis of Burkitt lymphoma.
KW - Burkitt lymphoma
KW - clinical presentation
KW - Head and neck
KW - prognosis
KW - symptom
U2 - 10.1080/00016489.2021.1918764
DO - 10.1080/00016489.2021.1918764
M3 - Journal article
C2 - 34275418
AN - SCOPUS:85110812498
VL - 141
SP - 812
EP - 819
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 8
ER -
ID: 301836697