Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 1,04 MB, PDF-dokument
Right ventricular (RV) dilatation predicts clinical worsening in pulmonary arterial hypertension (PAH) and RV volumes can be measured with high precision using cardiovascular magnetic resonance imaging. In regular follow-up of patients and in studies of improvement in RV function, knowledge of clinically significant changes of RV volumes and function are of relevance. Patients with PAH were followed with cardiovascular magnetic resonance imaging and clinical assessment at 6-month intervals. Changes in RV volumes associated with changes in clinical status were assessed. Twenty-five patients with PAH (Group 1) were included and examined every 6 months for 2.5 years, with a total of 107 MRI scans. For a step change in WHO functional class, the associated change in RV volume was 11% (confidence interval 7%−14%, p < 0.0001) and in stroke volume 9% (confidence interval 3%−15%, p = 0.003). This study found an 11% change in RV volume to be clinically significant. The combination of clinically significant changes and the known precision in the measurements enables individualized follow-up of RV-function in PAH. To our knowledge, this study is the first to use repeated assessments to suggest clinically significant changes of RV volume based on changes in clinical presentation.
Originalsprog | Engelsk |
---|---|
Artikelnummer | e12097 |
Tidsskrift | Pulmonary Circulation |
Vol/bind | 12 |
Udgave nummer | 3 |
ISSN | 2045-8932 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This study was funded by an investigator‐initiated study research grant from Janssen Pharmaceuticals. The sponsor did not participate in the study design, data collection, analysis interpretation, writing of the manuscript, or decision to submit the manuscript for publication.
Publisher Copyright:
© 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 329245458