Clinical presentation and mortality in hospitalized patients aged 80+ years with COVID-19–A retrospective cohort study
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Clinical presentation and mortality in hospitalized patients aged 80+ years with COVID-19–A retrospective cohort study. / Karlsson, Linda Katharina; Jakobsen, Lasse Hjort; Hollensberg, Louise; Ryg, Jesper; Midttun, Mette; Frederiksen, Henrik; Glenthøj, Andreas; Kodahl, Anette Raskov; Secher-Johnsen, Joanna; Nielsen, Lene Kongsgaard; Bofill, Nuria Gonzalez; Knudtzen, Fredrikke Christie; Lund, Cecilia Margareta.
I: Archives of Gerontology and Geriatrics, Bind 94, 104335, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Clinical presentation and mortality in hospitalized patients aged 80+ years with COVID-19–A retrospective cohort study
AU - Karlsson, Linda Katharina
AU - Jakobsen, Lasse Hjort
AU - Hollensberg, Louise
AU - Ryg, Jesper
AU - Midttun, Mette
AU - Frederiksen, Henrik
AU - Glenthøj, Andreas
AU - Kodahl, Anette Raskov
AU - Secher-Johnsen, Joanna
AU - Nielsen, Lene Kongsgaard
AU - Bofill, Nuria Gonzalez
AU - Knudtzen, Fredrikke Christie
AU - Lund, Cecilia Margareta
PY - 2021
Y1 - 2021
N2 - Background: COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has great health implications in older patients, including high mortality. In general, older patients often have atypical symptom presentations during acute illness due to a high level of comorbidity. The purpose of this study was to investigate the presentation of symptoms at hospital admissions in older patients with COVID-19 and evaluate its impact on disease outcome. Methods: This retrospective study included patients ≥80 years of age with a positive test for SARS-CoV-2, who were admitted to one of three medical departments in Denmark from March 1st to June 1st, 2020. Results: A total of 102 patients (47% male) with a mean age of 85 years were included. The most common symptoms at admission were fever (74%), cough (62%), and shortness of breath (54%). Furthermore, atypical symptoms like confusion (29%), difficulty walking (13%), and falls (8%) were also present. In-hospital and 30-day mortality were 31% (n = 32) and 41% (n = 42), respectively. Mortality was highest in patients with confusion (50% vs 38%) or falls (63% vs 39%), and nursing home residency prior to hospital admission was associated with higher mortality (OR 2.7, 95% CI 1.1–6.7). Conclusions: Older patients with SARS-Cov-2 displayed classical symptoms of COVID-19 but also geriatric frailty symptoms such as confusion and walking impairments. Additionally, both in-hospital and 30-day mortality was very high. Our study highlights the need for preventive efforts to keep older people from getting COVID-19 and increased awareness of frailty among those with COVID-19.
AB - Background: COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has great health implications in older patients, including high mortality. In general, older patients often have atypical symptom presentations during acute illness due to a high level of comorbidity. The purpose of this study was to investigate the presentation of symptoms at hospital admissions in older patients with COVID-19 and evaluate its impact on disease outcome. Methods: This retrospective study included patients ≥80 years of age with a positive test for SARS-CoV-2, who were admitted to one of three medical departments in Denmark from March 1st to June 1st, 2020. Results: A total of 102 patients (47% male) with a mean age of 85 years were included. The most common symptoms at admission were fever (74%), cough (62%), and shortness of breath (54%). Furthermore, atypical symptoms like confusion (29%), difficulty walking (13%), and falls (8%) were also present. In-hospital and 30-day mortality were 31% (n = 32) and 41% (n = 42), respectively. Mortality was highest in patients with confusion (50% vs 38%) or falls (63% vs 39%), and nursing home residency prior to hospital admission was associated with higher mortality (OR 2.7, 95% CI 1.1–6.7). Conclusions: Older patients with SARS-Cov-2 displayed classical symptoms of COVID-19 but also geriatric frailty symptoms such as confusion and walking impairments. Additionally, both in-hospital and 30-day mortality was very high. Our study highlights the need for preventive efforts to keep older people from getting COVID-19 and increased awareness of frailty among those with COVID-19.
KW - Delirium
KW - Falls
KW - Frailty
KW - Multimorbidities
KW - SARS-CoV-2
U2 - 10.1016/j.archger.2020.104335
DO - 10.1016/j.archger.2020.104335
M3 - Journal article
C2 - 33476754
AN - SCOPUS:85100207797
VL - 94
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
M1 - 104335
ER -
ID: 256628232