TY - JOUR

T1 - Circulating microRNAs in breast cancer

T2 - novel diagnostic and prognostic biomarkers

AU - Hamam, Rimi

AU - Hamam, Dana

AU - Alsaleh, Khalid A.

AU - Kassem, Moustapha

AU - Zaher, Waleed

AU - Alfayez, Musaad

AU - Aldahmash, Abdullah

AU - Alajez, Nehad M.

PY - 2017

Y1 - 2017

N2 - Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years has highlighted the potential use of peripheral blood circulating nucleic acids such as DNA, mRNA and micro (mi)RNA in breast cancer diagnosis, prognosis and for monitoring response to anticancer therapy. Among these, circulating miRNA is increasingly recognized as a promising biomarker, given the ease with which miRNAs can be isolated and their structural stability under different conditions of sample processing and isolation. In this review, we provide current state-of-the-art of miRNA biogenesis, function and discuss the advantages, limitations, as well as pitfalls of using circulating miRNAs as diagnostic, prognostic or predictive biomarkers in breast cancer management.

AB - Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years has highlighted the potential use of peripheral blood circulating nucleic acids such as DNA, mRNA and micro (mi)RNA in breast cancer diagnosis, prognosis and for monitoring response to anticancer therapy. Among these, circulating miRNA is increasingly recognized as a promising biomarker, given the ease with which miRNAs can be isolated and their structural stability under different conditions of sample processing and isolation. In this review, we provide current state-of-the-art of miRNA biogenesis, function and discuss the advantages, limitations, as well as pitfalls of using circulating miRNAs as diagnostic, prognostic or predictive biomarkers in breast cancer management.

U2 - 10.1038/cddis.2017.440

DO - 10.1038/cddis.2017.440

M3 - Journal article

C2 - 28880270

VL - 8

JO - Cell Death & Disease

JF - Cell Death & Disease

SN - 2041-4889

IS - 9

M1 - e3045

ER -