Standard
Chromosome errors in human eggs shape natural fertility over reproductive life span. / Gruhn, Jennifer R; Zielinska, Agata P; Shukla, Vallari; Blanshard, Robert; Capalbo, Antonio; Cimadomo, Danilo; Nikiforov, Dmitry; Chan, Andrew Chi-Ho; Newnham, Louise J; Vogel, Ivan; Scarica, Catello; Krapchev, Marta; Taylor, Deborah; Kristensen, Stine Gry; Cheng, Junping; Ernst, Erik; Bjørn, Anne-Mette Bay; Colmorn, Lotte Berdiin; Blayney, Martyn; Elder, Kay; Liss, Joanna; Hartshorne, Geraldine; Grøndahl, Marie Louise; Rienzi, Laura; Ubaldi, Filippo; McCoy, Rajiv; Lukaszuk, Krzysztof; Andersen, Claus Yding; Schuh, Melina; Hoffmann, Eva R.
I:
Science (New York, N.Y.), Bind 365, Nr. 6460, 2019, s. 1466-1469.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Gruhn, JR, Zielinska, AP, Shukla, V, Blanshard, R, Capalbo, A, Cimadomo, D, Nikiforov, D
, Chan, AC-H, Newnham, LJ
, Vogel, I, Scarica, C, Krapchev, M, Taylor, D, Kristensen, SG, Cheng, J, Ernst, E, Bjørn, A-MB, Colmorn, LB, Blayney, M, Elder, K, Liss, J, Hartshorne, G, Grøndahl, ML, Rienzi, L, Ubaldi, F, McCoy, R, Lukaszuk, K
, Andersen, CY, Schuh, M
& Hoffmann, ER 2019, '
Chromosome errors in human eggs shape natural fertility over reproductive life span',
Science (New York, N.Y.), bind 365, nr. 6460, s. 1466-1469.
https://doi.org/10.1126/science.aav7321
APA
Gruhn, J. R., Zielinska, A. P., Shukla, V., Blanshard, R., Capalbo, A., Cimadomo, D., Nikiforov, D.
, Chan, A. C-H., Newnham, L. J.
, Vogel, I., Scarica, C., Krapchev, M., Taylor, D., Kristensen, S. G., Cheng, J., Ernst, E., Bjørn, A-M. B., Colmorn, L. B., Blayney, M.
, ... Hoffmann, E. R. (2019).
Chromosome errors in human eggs shape natural fertility over reproductive life span.
Science (New York, N.Y.),
365(6460), 1466-1469.
https://doi.org/10.1126/science.aav7321
Vancouver
Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D o.a.
Chromosome errors in human eggs shape natural fertility over reproductive life span.
Science (New York, N.Y.). 2019;365(6460):1466-1469.
https://doi.org/10.1126/science.aav7321
Author
Gruhn, Jennifer R ; Zielinska, Agata P ; Shukla, Vallari ; Blanshard, Robert ; Capalbo, Antonio ; Cimadomo, Danilo ; Nikiforov, Dmitry ; Chan, Andrew Chi-Ho ; Newnham, Louise J ; Vogel, Ivan ; Scarica, Catello ; Krapchev, Marta ; Taylor, Deborah ; Kristensen, Stine Gry ; Cheng, Junping ; Ernst, Erik ; Bjørn, Anne-Mette Bay ; Colmorn, Lotte Berdiin ; Blayney, Martyn ; Elder, Kay ; Liss, Joanna ; Hartshorne, Geraldine ; Grøndahl, Marie Louise ; Rienzi, Laura ; Ubaldi, Filippo ; McCoy, Rajiv ; Lukaszuk, Krzysztof ; Andersen, Claus Yding ; Schuh, Melina ; Hoffmann, Eva R. / Chromosome errors in human eggs shape natural fertility over reproductive life span. I: Science (New York, N.Y.). 2019 ; Bind 365, Nr. 6460. s. 1466-1469.
Bibtex
@article{4c3dace8381c439e8a2fc10c9a5b78ab,
title = "Chromosome errors in human eggs shape natural fertility over reproductive life span",
abstract = "Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.",
author = "Gruhn, {Jennifer R} and Zielinska, {Agata P} and Vallari Shukla and Robert Blanshard and Antonio Capalbo and Danilo Cimadomo and Dmitry Nikiforov and Chan, {Andrew Chi-Ho} and Newnham, {Louise J} and Ivan Vogel and Catello Scarica and Marta Krapchev and Deborah Taylor and Kristensen, {Stine Gry} and Junping Cheng and Erik Ernst and Bj{\o}rn, {Anne-Mette Bay} and Colmorn, {Lotte Berdiin} and Martyn Blayney and Kay Elder and Joanna Liss and Geraldine Hartshorne and Gr{\o}ndahl, {Marie Louise} and Laura Rienzi and Filippo Ubaldi and Rajiv McCoy and Krzysztof Lukaszuk and Andersen, {Claus Yding} and Melina Schuh and Hoffmann, {Eva R}",
note = "Copyright {\textcopyright} 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2019",
doi = "10.1126/science.aav7321",
language = "English",
volume = "365",
pages = "1466--1469",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6460",
}
RIS
TY - JOUR
T1 - Chromosome errors in human eggs shape natural fertility over reproductive life span
AU - Gruhn, Jennifer R
AU - Zielinska, Agata P
AU - Shukla, Vallari
AU - Blanshard, Robert
AU - Capalbo, Antonio
AU - Cimadomo, Danilo
AU - Nikiforov, Dmitry
AU - Chan, Andrew Chi-Ho
AU - Newnham, Louise J
AU - Vogel, Ivan
AU - Scarica, Catello
AU - Krapchev, Marta
AU - Taylor, Deborah
AU - Kristensen, Stine Gry
AU - Cheng, Junping
AU - Ernst, Erik
AU - Bjørn, Anne-Mette Bay
AU - Colmorn, Lotte Berdiin
AU - Blayney, Martyn
AU - Elder, Kay
AU - Liss, Joanna
AU - Hartshorne, Geraldine
AU - Grøndahl, Marie Louise
AU - Rienzi, Laura
AU - Ubaldi, Filippo
AU - McCoy, Rajiv
AU - Lukaszuk, Krzysztof
AU - Andersen, Claus Yding
AU - Schuh, Melina
AU - Hoffmann, Eva R
N1 - Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PY - 2019
Y1 - 2019
N2 - Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.
AB - Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.
U2 - 10.1126/science.aav7321
DO - 10.1126/science.aav7321
M3 - Journal article
C2 - 31604276
VL - 365
SP - 1466
EP - 1469
JO - Science
JF - Science
SN - 0036-8075
IS - 6460
ER -