Cholecystokinin and panic disorder: Reflections on the history and some unsolved questions

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Cholecystokinin and panic disorder : Reflections on the history and some unsolved questions. / Rehfeld, Jens F.

I: Molecules, Bind 26, Nr. 18, 5657, 2021.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Rehfeld, JF 2021, 'Cholecystokinin and panic disorder: Reflections on the history and some unsolved questions', Molecules, bind 26, nr. 18, 5657. https://doi.org/10.3390/molecules26185657

APA

Rehfeld, J. F. (2021). Cholecystokinin and panic disorder: Reflections on the history and some unsolved questions. Molecules, 26(18), [5657]. https://doi.org/10.3390/molecules26185657

Vancouver

Rehfeld JF. Cholecystokinin and panic disorder: Reflections on the history and some unsolved questions. Molecules. 2021;26(18). 5657. https://doi.org/10.3390/molecules26185657

Author

Rehfeld, Jens F. / Cholecystokinin and panic disorder : Reflections on the history and some unsolved questions. I: Molecules. 2021 ; Bind 26, Nr. 18.

Bibtex

@article{d34bdcf4d3364d9884c885eaf1c29863,
title = "Cholecystokinin and panic disorder: Reflections on the history and some unsolved questions",
abstract = "The classic gut hormone cholecystokinin (CCK) and its CCK2-receptor are expressed in almost all regions of the brain. This widespread expression makes CCK by far the most abundant peptidergic transmitter system in the brain. This CNS-ubiquity has, however, complicated the de-lineation of the roles of CCK peptides in normal brain functions and neuropsychiatric diseases. Nev-ertheless, the common panic disorder disease is apparently associated with CCK in the brain. Thus, the C-terminal tetrapeptide fragment of CCK (CCK-4) induces, by intravenous administration in a dose-related manner, panic attacks that are similar to the endogenous attacks in panic disorder pa-tients. This review describes the history behind the discovery of the panicogenic effect of CCK-4. Subsequently, the review discusses three unsettled questions about the involvement of cerebral CCK in the pathogenesis of anxiety and panic disorder, including therapeutic attempts with CCK2-receptor antagonists.",
keywords = "Anxiety, Cholecystokinin (CCK), Neuropeptides, Panic disorder, Panicogenicity, Peptidergic neurotransmission",
author = "Rehfeld, {Jens F.}",
note = "Publisher Copyright: {\textcopyright} 2021 by the author. Licensee MDPI, Basel, Switzerland.",
year = "2021",
doi = "10.3390/molecules26185657",
language = "English",
volume = "26",
journal = "Molecules",
issn = "1420-3049",
publisher = "M D P I AG",
number = "18",

}

RIS

TY - JOUR

T1 - Cholecystokinin and panic disorder

T2 - Reflections on the history and some unsolved questions

AU - Rehfeld, Jens F.

N1 - Publisher Copyright: © 2021 by the author. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - The classic gut hormone cholecystokinin (CCK) and its CCK2-receptor are expressed in almost all regions of the brain. This widespread expression makes CCK by far the most abundant peptidergic transmitter system in the brain. This CNS-ubiquity has, however, complicated the de-lineation of the roles of CCK peptides in normal brain functions and neuropsychiatric diseases. Nev-ertheless, the common panic disorder disease is apparently associated with CCK in the brain. Thus, the C-terminal tetrapeptide fragment of CCK (CCK-4) induces, by intravenous administration in a dose-related manner, panic attacks that are similar to the endogenous attacks in panic disorder pa-tients. This review describes the history behind the discovery of the panicogenic effect of CCK-4. Subsequently, the review discusses three unsettled questions about the involvement of cerebral CCK in the pathogenesis of anxiety and panic disorder, including therapeutic attempts with CCK2-receptor antagonists.

AB - The classic gut hormone cholecystokinin (CCK) and its CCK2-receptor are expressed in almost all regions of the brain. This widespread expression makes CCK by far the most abundant peptidergic transmitter system in the brain. This CNS-ubiquity has, however, complicated the de-lineation of the roles of CCK peptides in normal brain functions and neuropsychiatric diseases. Nev-ertheless, the common panic disorder disease is apparently associated with CCK in the brain. Thus, the C-terminal tetrapeptide fragment of CCK (CCK-4) induces, by intravenous administration in a dose-related manner, panic attacks that are similar to the endogenous attacks in panic disorder pa-tients. This review describes the history behind the discovery of the panicogenic effect of CCK-4. Subsequently, the review discusses three unsettled questions about the involvement of cerebral CCK in the pathogenesis of anxiety and panic disorder, including therapeutic attempts with CCK2-receptor antagonists.

KW - Anxiety

KW - Cholecystokinin (CCK)

KW - Neuropeptides

KW - Panic disorder

KW - Panicogenicity

KW - Peptidergic neurotransmission

U2 - 10.3390/molecules26185657

DO - 10.3390/molecules26185657

M3 - Review

C2 - 34577128

AN - SCOPUS:85115388691

VL - 26

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 18

M1 - 5657

ER -

ID: 303771231