Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens

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Standard

Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens. / Buus, S; Werdelin, O.

I: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, Bind 92, Nr. 5, 1984, s. 285-91.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Buus, S & Werdelin, O 1984, 'Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens', APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, bind 92, nr. 5, s. 285-91.

APA

Buus, S., & Werdelin, O. (1984). Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens. APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, 92(5), 285-91.

Vancouver

Buus S, Werdelin O. Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens. APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 1984;92(5):285-91.

Author

Buus, S ; Werdelin, O. / Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens. I: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 1984 ; Bind 92, Nr. 5. s. 285-91.

Bibtex

@article{db9a0f40ebce11ddbf70000ea68e967b,
title = "Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens",
abstract = "We have studied the in vitro effect of the lysosomotrophic agent, chloroquine, on the presentation of soluble protein antigens by guinea pig accessory cells. Chloroquine inhibited the capacity of antigen-pulsed accessory cells to stimulate proliferation in appropriately primed T cells. The effect was time- and dose-dependent. A brief treatment solely of the accessory cells with the drug compromised their ability to stimulate primed T cells in a subsequent culture provided the accessory cells were treated with chloroquine before their exposure to the antigen. These results suggest that chloroquine acts on an early event in the antigen handling by accessory cells. Chloroquine is a well known inhibitor of lysosomal proteolysis, and it is likely that its effect on antigen presentation is caused by an inhibition of antigen degradation.",
author = "S Buus and O Werdelin",
note = "Keywords: Animals; Antigen-Presenting Cells; Cells, Cultured; Chloroquine; Guinea Pigs; Latex; Lymphocyte Activation; Macrophages; Phagocytosis; T-Lymphocytes",
year = "1984",
language = "English",
volume = "92",
pages = "285--91",
journal = "APMIS. Supplementum",
issn = "0903-465X",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Chloroquine inhibits accessory cell presentation of soluble natural and synthetic protein antigens

AU - Buus, S

AU - Werdelin, O

N1 - Keywords: Animals; Antigen-Presenting Cells; Cells, Cultured; Chloroquine; Guinea Pigs; Latex; Lymphocyte Activation; Macrophages; Phagocytosis; T-Lymphocytes

PY - 1984

Y1 - 1984

N2 - We have studied the in vitro effect of the lysosomotrophic agent, chloroquine, on the presentation of soluble protein antigens by guinea pig accessory cells. Chloroquine inhibited the capacity of antigen-pulsed accessory cells to stimulate proliferation in appropriately primed T cells. The effect was time- and dose-dependent. A brief treatment solely of the accessory cells with the drug compromised their ability to stimulate primed T cells in a subsequent culture provided the accessory cells were treated with chloroquine before their exposure to the antigen. These results suggest that chloroquine acts on an early event in the antigen handling by accessory cells. Chloroquine is a well known inhibitor of lysosomal proteolysis, and it is likely that its effect on antigen presentation is caused by an inhibition of antigen degradation.

AB - We have studied the in vitro effect of the lysosomotrophic agent, chloroquine, on the presentation of soluble protein antigens by guinea pig accessory cells. Chloroquine inhibited the capacity of antigen-pulsed accessory cells to stimulate proliferation in appropriately primed T cells. The effect was time- and dose-dependent. A brief treatment solely of the accessory cells with the drug compromised their ability to stimulate primed T cells in a subsequent culture provided the accessory cells were treated with chloroquine before their exposure to the antigen. These results suggest that chloroquine acts on an early event in the antigen handling by accessory cells. Chloroquine is a well known inhibitor of lysosomal proteolysis, and it is likely that its effect on antigen presentation is caused by an inhibition of antigen degradation.

M3 - Journal article

C2 - 6334972

VL - 92

SP - 285

EP - 291

JO - APMIS. Supplementum

JF - APMIS. Supplementum

SN - 0903-465X

IS - 5

ER -

ID: 9948467