Chest x-ray imaging score is associated with severity of COVID-19 pneumonia: the MBrixia score
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Spatial resolution in existing chest x-ray (CXR)-based scoring systems for coronavirus disease 2019 (COVID-19) pneumonia is low, and should be increased for better representation of anatomy, and severity of lung involvement. An existing CXR-based system, the Brixia score, was modified to increase the spatial resolution, creating the MBrixia score. The MBrixia score is the sum, of a rule-based quantification of CXR severity on a scale of 0 to 3 in 12 anatomical zones in the lungs. The MBrixia score was applied to CXR images from COVID-19 patients at a single tertiary hospital in the period May 4th–June 5th, 2020. The relationship between MBrixia score, and level of respiratory support at the time of performed CXR imaging was investigated. 37 hospitalized COVID-19 patients with 290 CXRs were identified, 22 (59.5%) were admitted to the intensive care unit and 10 (27%) died during follow-up. In a Poisson regression using all 290 MBrixia scored CXRs, a higher MBrixia score was associated with a higher level of respiratory support at the time of performed CXR. The MBrixia score could potentially be valuable as a quantitative surrogate measurement of COVID-19 pneumonia severity, and future studies should investigate the score’s validity and capabilities of predicting clinical outcomes.
Originalsprog | Engelsk |
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Artikelnummer | 21019 |
Tidsskrift | Scientific Reports |
Vol/bind | 12 |
ISSN | 2045-2322 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This work was supported by the Danish National Research Foundation [Grant Number 126]; the Danish Ministry of Higher Education and Science [Grant Number 0238-00006B] to SRO and CUN; Rigshospitalet [Grant Number E-23641-03] to CMJ; and the Novo Nordisk Foundation [Grant Number NNF20SA0063191] to JDL.
Funding Information:
We acknowledge the IT team at CHIP, Section 2100 Rigshospitalet, for exceptional IT assistance as well as the Department of Diagnostic Radiology, Rigshospitalet, for their excellent work. Finally, we acknowledge the clinical staff working during the pandemic.
Publisher Copyright:
© 2022, The Author(s).
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