Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients
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Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients. / Laroy, Maarten; Bouckaert, Filip; Ousdal, Olga Therese; Dols, Annemieke; Rhebergen, Didi; van Exel, Eric; van Wingen, Guido; van Waarde, Jeroen; Verdijk, Joey; Kessler, Ute; Bartsch, Hauke; Jorgensen, Martin Balslev; Paulson, Olaf B.; Nordanskog, Pia; Prudic, Joan; Sienaert, Pascal; Vandenbulcke, Mathieu; Oltedal, Leif; Emsell, Louise; for GEMRIC.
I: Brain Stimulation, Bind 17, Nr. 4, 2024, s. 876-886.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients
AU - Laroy, Maarten
AU - Bouckaert, Filip
AU - Ousdal, Olga Therese
AU - Dols, Annemieke
AU - Rhebergen, Didi
AU - van Exel, Eric
AU - van Wingen, Guido
AU - van Waarde, Jeroen
AU - Verdijk, Joey
AU - Kessler, Ute
AU - Bartsch, Hauke
AU - Jorgensen, Martin Balslev
AU - Paulson, Olaf B.
AU - Nordanskog, Pia
AU - Prudic, Joan
AU - Sienaert, Pascal
AU - Vandenbulcke, Mathieu
AU - Oltedal, Leif
AU - Emsell, Louise
AU - for GEMRIC
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Background: Increased gray matter volume (GMV) following electroconvulsive therapy (ECT) has been well-documented, with limited studies reporting a subsequent decrease in GMV afterwards. Objective: This study characterized the reversion pattern of GMV after ECT and its association with clinical depression outcome, using multi-site triple time-point data from the Global ECT-MRI Research Collaboration (GEMRIC). Methods: 86 subjects from the GEMRIC database were included, and GMV in 84 regions-of-interest (ROI) was obtained from automatic segmentation of T1 MRI images at three timepoints: pre-ECT (T0), within one-week post-ECT (T1), and one to six months post-ECT (T2). RM-ANOVAs were used to assess longitudinal changes and LMM analyses explored associations between GMV changes and demographical and clinical characteristics. Results: 63 of the 84 ROIs showed a significant increase-and-decrease pattern (RM-ANOVA, Bonferroni corrected p < 0.00059). Post hoc tests indicated a consistent pattern in each of these 63 ROIs: significant increase from T0 to T1inGMV, followed by significant decrease from T1 to T2 and no difference between T0 and T2, except for both amygdalae, right hippocampus and pars triangularis, which showed the same increase and decrease but GMV at T2 remained higher compared to T0. No consistent relationship was found between GMV change pattern and clinical status. Conclusion: The GEMRIC cohort confirmed a rapid increase of GMV after ECT followed by reversion of GMV one to six months thereafter. The lack of association between the GMV change pattern and depression outcome scores implies a transient neurobiological effect of ECT unrelated to clinical improvement.
AB - Background: Increased gray matter volume (GMV) following electroconvulsive therapy (ECT) has been well-documented, with limited studies reporting a subsequent decrease in GMV afterwards. Objective: This study characterized the reversion pattern of GMV after ECT and its association with clinical depression outcome, using multi-site triple time-point data from the Global ECT-MRI Research Collaboration (GEMRIC). Methods: 86 subjects from the GEMRIC database were included, and GMV in 84 regions-of-interest (ROI) was obtained from automatic segmentation of T1 MRI images at three timepoints: pre-ECT (T0), within one-week post-ECT (T1), and one to six months post-ECT (T2). RM-ANOVAs were used to assess longitudinal changes and LMM analyses explored associations between GMV changes and demographical and clinical characteristics. Results: 63 of the 84 ROIs showed a significant increase-and-decrease pattern (RM-ANOVA, Bonferroni corrected p < 0.00059). Post hoc tests indicated a consistent pattern in each of these 63 ROIs: significant increase from T0 to T1inGMV, followed by significant decrease from T1 to T2 and no difference between T0 and T2, except for both amygdalae, right hippocampus and pars triangularis, which showed the same increase and decrease but GMV at T2 remained higher compared to T0. No consistent relationship was found between GMV change pattern and clinical status. Conclusion: The GEMRIC cohort confirmed a rapid increase of GMV after ECT followed by reversion of GMV one to six months thereafter. The lack of association between the GMV change pattern and depression outcome scores implies a transient neurobiological effect of ECT unrelated to clinical improvement.
KW - Brain
KW - Depression
KW - ECT
KW - Magnetic resonance imaging
KW - Neuroimaging
KW - Neuroplasticity
U2 - 10.1016/j.brs.2024.07.015
DO - 10.1016/j.brs.2024.07.015
M3 - Journal article
C2 - 39059711
AN - SCOPUS:85199569772
VL - 17
SP - 876
EP - 886
JO - Brain Stimulation
JF - Brain Stimulation
SN - 1935-861X
IS - 4
ER -
ID: 400704903