Characterization of ex vivo expanded tumor infiltrating lymphocytes from patients with malignant melanoma for clinical application
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Characterization of ex vivo expanded tumor infiltrating lymphocytes from patients with malignant melanoma for clinical application. / Junker, Niels; Thor Straten, Per; Andersen, Mads Hald; Svane, Inge Marie.
I: Journal of Skin Cancer, Bind 2011, Nr. 574695, 2011.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Characterization of ex vivo expanded tumor infiltrating lymphocytes from patients with malignant melanoma for clinical application
AU - Junker, Niels
AU - Thor Straten, Per
AU - Andersen, Mads Hald
AU - Svane, Inge Marie
PY - 2011
Y1 - 2011
N2 - Clinical trials of adoptive transfer of autologous tumor infiltrating lymphocytes (TILs) to patients with advanced malignant melanoma have shown remarkable results with objective clinical responses in 50% of the treated patients. In order to initiate a clinical trial in melanoma, we have established a method for expanding TILs to clinical relevant quantities in two steps with in 8 weeks. Further characterization of expanded TILs revealed an oligoclonal composition of T-cells with an effector memory like phenotype. When autologous tumor was available, TILs showed specific activity in all patients tested. TIL cultures contained specificity towards tumor cells as well as peptides derived from tumor-associated antigens (TAAs) during expansion procedures.
AB - Clinical trials of adoptive transfer of autologous tumor infiltrating lymphocytes (TILs) to patients with advanced malignant melanoma have shown remarkable results with objective clinical responses in 50% of the treated patients. In order to initiate a clinical trial in melanoma, we have established a method for expanding TILs to clinical relevant quantities in two steps with in 8 weeks. Further characterization of expanded TILs revealed an oligoclonal composition of T-cells with an effector memory like phenotype. When autologous tumor was available, TILs showed specific activity in all patients tested. TIL cultures contained specificity towards tumor cells as well as peptides derived from tumor-associated antigens (TAAs) during expansion procedures.
U2 - http://dx.doi.org/10.1155/2011/574695
DO - http://dx.doi.org/10.1155/2011/574695
M3 - Journal article
VL - 2011
JO - Journal of Skin Cancer
JF - Journal of Skin Cancer
SN - 2090-2905
IS - 574695
ER -
ID: 40197080