Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years: a prospective cohort study
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Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years : a prospective cohort study. / Kim, Jae Hyun; Lee, Young Ah; Lim, Youn-Hee; Lee, Kyunghoon; Kim, Bung-Nyun; Kim, Johanna Inhyang; Hong, Yun-Chul; Yang, Sei Won; Song, Junghan; Shin, Choong Ho.
I: The Journal of clinical endocrinology and metabolism, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Changes in adrenal androgens and steroidogenic enzyme activities from ages 2, 4, to 6 years
T2 - a prospective cohort study
AU - Kim, Jae Hyun
AU - Lee, Young Ah
AU - Lim, Youn-Hee
AU - Lee, Kyunghoon
AU - Kim, Bung-Nyun
AU - Kim, Johanna Inhyang
AU - Hong, Yun-Chul
AU - Yang, Sei Won
AU - Song, Junghan
AU - Shin, Choong Ho
N1 - © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2020
Y1 - 2020
N2 - CONTEXT: The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.OBJECTIVE: We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood.DESIGN AND PARTICIPANTS: From a prospective children's cohort, the Environment and Development of Children (EDC) cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included.OUTCOME MEASUREMENTS: Serum concentrations of adrenal androgens using liquid chromatography-tandem mass spectrometry and steroidogenic enzyme activity calculated by the precursor/product ratio.RESULTS: During ages 2-4 years, 17,20-lyase and dehydroepiandrosterone (DHEA) sulfotransferase activities increased (P<0.01 for both in boys). During ages 4-6 years, 17,20-lyase activity persistently increased, but 3β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities decreased (P<0.01 for all). Serum DHEA sulfate (DHEA-S) levels persistently increased from 2, 4, to 6 years, and DHEA, 17-hydroxyprogesterone, and androstenedione levels increased during ages 4-6 years (P<0.01 for all). Serum DHEA-S levels during early childhood were associated with body mass index z-scores (P=0.001 in only boys).CONCLUSION: This study supports in vivo human evidence of increased 17,20-lyase and DHEA sulfotransferase activities and decreased 3β-HSD activity during early childhood.
AB - CONTEXT: The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis.OBJECTIVE: We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood.DESIGN AND PARTICIPANTS: From a prospective children's cohort, the Environment and Development of Children (EDC) cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included.OUTCOME MEASUREMENTS: Serum concentrations of adrenal androgens using liquid chromatography-tandem mass spectrometry and steroidogenic enzyme activity calculated by the precursor/product ratio.RESULTS: During ages 2-4 years, 17,20-lyase and dehydroepiandrosterone (DHEA) sulfotransferase activities increased (P<0.01 for both in boys). During ages 4-6 years, 17,20-lyase activity persistently increased, but 3β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities decreased (P<0.01 for all). Serum DHEA sulfate (DHEA-S) levels persistently increased from 2, 4, to 6 years, and DHEA, 17-hydroxyprogesterone, and androstenedione levels increased during ages 4-6 years (P<0.01 for all). Serum DHEA-S levels during early childhood were associated with body mass index z-scores (P=0.001 in only boys).CONCLUSION: This study supports in vivo human evidence of increased 17,20-lyase and DHEA sulfotransferase activities and decreased 3β-HSD activity during early childhood.
U2 - 10.1210/clinem/dgaa498
DO - 10.1210/clinem/dgaa498
M3 - Journal article
C2 - 32750115
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
ER -
ID: 246601480