CGRP in human models of primary headaches

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

CGRP in human models of primary headaches. / Ashina, Håkan; Schytz, Henrik Winther; Ashina, Messoud.

I: Cephalalgia : an international journal of headache, Bind 38, Nr. 2, 2018, s. 353-360.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Ashina, H, Schytz, HW & Ashina, M 2018, 'CGRP in human models of primary headaches', Cephalalgia : an international journal of headache, bind 38, nr. 2, s. 353-360. https://doi.org/10.1177/0333102416684344

APA

Ashina, H., Schytz, H. W., & Ashina, M. (2018). CGRP in human models of primary headaches. Cephalalgia : an international journal of headache, 38(2), 353-360. https://doi.org/10.1177/0333102416684344

Vancouver

Ashina H, Schytz HW, Ashina M. CGRP in human models of primary headaches. Cephalalgia : an international journal of headache. 2018;38(2):353-360. https://doi.org/10.1177/0333102416684344

Author

Ashina, Håkan ; Schytz, Henrik Winther ; Ashina, Messoud. / CGRP in human models of primary headaches. I: Cephalalgia : an international journal of headache. 2018 ; Bind 38, Nr. 2. s. 353-360.

Bibtex

@article{ad270282a19e46bd8767dc10e5adf0d3,
title = "CGRP in human models of primary headaches",
abstract = "Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.",
keywords = "Analgesics/pharmacology, Biomarkers/metabolism, Calcitonin Gene-Related Peptide/antagonists & inhibitors, Cluster Headache/diagnosis, Humans, Migraine Disorders/diagnosis, Tension-Type Headache/diagnosis",
author = "H{\aa}kan Ashina and Schytz, {Henrik Winther} and Messoud Ashina",
year = "2018",
doi = "10.1177/0333102416684344",
language = "English",
volume = "38",
pages = "353--360",
journal = "Cephalalgia",
issn = "0800-1952",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - CGRP in human models of primary headaches

AU - Ashina, Håkan

AU - Schytz, Henrik Winther

AU - Ashina, Messoud

PY - 2018

Y1 - 2018

N2 - Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.

AB - Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.

KW - Analgesics/pharmacology

KW - Biomarkers/metabolism

KW - Calcitonin Gene-Related Peptide/antagonists & inhibitors

KW - Cluster Headache/diagnosis

KW - Humans

KW - Migraine Disorders/diagnosis

KW - Tension-Type Headache/diagnosis

U2 - 10.1177/0333102416684344

DO - 10.1177/0333102416684344

M3 - Review

C2 - 27940880

VL - 38

SP - 353

EP - 360

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 2

ER -

ID: 215867602