CGRP in Human Models of Migraine

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

CGRP in Human Models of Migraine. / Ashina, Håkan; Schytz, Henrik Winther; Ashina, Messoud.

Calcitonin Gene-Related Peptide (CGRP) Mechanisms. red. / S. Brian; P. Geppetti. Bind 255 Springer, 2019. s. 109-120 (Handbook of Experimental Pharmacology).

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

Ashina, H, Schytz, HW & Ashina, M 2019, CGRP in Human Models of Migraine. i S Brian & P Geppetti (red), Calcitonin Gene-Related Peptide (CGRP) Mechanisms. bind 255, Springer, Handbook of Experimental Pharmacology, s. 109-120. https://doi.org/10.1007/164_2018_128

APA

Ashina, H., Schytz, H. W., & Ashina, M. (2019). CGRP in Human Models of Migraine. I S. Brian, & P. Geppetti (red.), Calcitonin Gene-Related Peptide (CGRP) Mechanisms (Bind 255, s. 109-120). Springer. Handbook of Experimental Pharmacology https://doi.org/10.1007/164_2018_128

Vancouver

Ashina H, Schytz HW, Ashina M. CGRP in Human Models of Migraine. I Brian S, Geppetti P, red., Calcitonin Gene-Related Peptide (CGRP) Mechanisms. Bind 255. Springer. 2019. s. 109-120. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/164_2018_128

Author

Ashina, Håkan ; Schytz, Henrik Winther ; Ashina, Messoud. / CGRP in Human Models of Migraine. Calcitonin Gene-Related Peptide (CGRP) Mechanisms. red. / S. Brian ; P. Geppetti. Bind 255 Springer, 2019. s. 109-120 (Handbook of Experimental Pharmacology).

Bibtex

@inbook{560ddc5aaf474cce905254c91c530470,

title = "CGRP in Human Models of Migraine",

abstract = "Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key molecule. Provocation experiments have demonstrated that intravenous CGRP infusion induces migraine-like attacks in migraine with and without aura patients. In addition, these studies have revealed a heterogeneous CGRP response, i.e., some migraine patients develop migraine-like attacks after CGRP infusion, while others do not. The role of CGRP in human migraine models has pointed to three potential sites of CGRP-induced migraine: (1) vasodilation via cyclic adenosine monophosphate (cAMP) and possibly cyclic guanosine monophosphate (cGMP); (2) activation of trigeminal sensory afferents, and (3) modulation of deep brain structures. In the future, refined human experimental studies will continue to unveil the role of CGRP in migraine pathogenesis.",

keywords = "Calcitonin/pharmacology, Calcitonin Gene-Related Peptide/genetics, Cyclic AMP, Cyclic GMP, Humans, Migraine Disorders/therapy",

author = "H{\aa}kan Ashina and Schytz, {Henrik Winther} and Messoud Ashina",

year = "2019",

doi = "10.1007/164_2018_128",

language = "English",

isbn = "978-3-030-21453-1",

volume = "255",

series = "Handbook of Experimental Pharmacology",

publisher = "Springer",

pages = "109--120",

editor = "S. Brian and P. Geppetti",

booktitle = "Calcitonin Gene-Related Peptide (CGRP) Mechanisms",

address = "Switzerland",

}

RIS

TY - CHAP

T1 - CGRP in Human Models of Migraine

AU - Ashina, Håkan

AU - Schytz, Henrik Winther

AU - Ashina, Messoud

PY - 2019

Y1 - 2019

N2 - Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key molecule. Provocation experiments have demonstrated that intravenous CGRP infusion induces migraine-like attacks in migraine with and without aura patients. In addition, these studies have revealed a heterogeneous CGRP response, i.e., some migraine patients develop migraine-like attacks after CGRP infusion, while others do not. The role of CGRP in human migraine models has pointed to three potential sites of CGRP-induced migraine: (1) vasodilation via cyclic adenosine monophosphate (cAMP) and possibly cyclic guanosine monophosphate (cGMP); (2) activation of trigeminal sensory afferents, and (3) modulation of deep brain structures. In the future, refined human experimental studies will continue to unveil the role of CGRP in migraine pathogenesis.

AB - Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key molecule. Provocation experiments have demonstrated that intravenous CGRP infusion induces migraine-like attacks in migraine with and without aura patients. In addition, these studies have revealed a heterogeneous CGRP response, i.e., some migraine patients develop migraine-like attacks after CGRP infusion, while others do not. The role of CGRP in human migraine models has pointed to three potential sites of CGRP-induced migraine: (1) vasodilation via cyclic adenosine monophosphate (cAMP) and possibly cyclic guanosine monophosphate (cGMP); (2) activation of trigeminal sensory afferents, and (3) modulation of deep brain structures. In the future, refined human experimental studies will continue to unveil the role of CGRP in migraine pathogenesis.

KW - Calcitonin/pharmacology

KW - Calcitonin Gene-Related Peptide/genetics

KW - Cyclic AMP

KW - Cyclic GMP

KW - Humans

KW - Migraine Disorders/therapy

U2 - 10.1007/164_2018_128

DO - 10.1007/164_2018_128

M3 - Book chapter

C2 - 29896653

SN - 978-3-030-21453-1

VL - 255

T3 - Handbook of Experimental Pharmacology

SP - 109

EP - 120

BT - Calcitonin Gene-Related Peptide (CGRP) Mechanisms

A2 - Brian, S.

A2 - Geppetti, P.

PB - Springer

ER -

ID: 233589735