Cerebrovascular effects of the converting enzyme inhibitor captopril

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Standard

Cerebrovascular effects of the converting enzyme inhibitor captopril. / Jarden, J O; Barry, D I; Strandgaard, S; Graham, D I; Paulson, O B.

I: Journal of Hypertension, Bind 1, Nr. Suppl2, 12.1983, s. 126-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jarden, JO, Barry, DI, Strandgaard, S, Graham, DI & Paulson, OB 1983, 'Cerebrovascular effects of the converting enzyme inhibitor captopril', Journal of Hypertension, bind 1, nr. Suppl2, s. 126-8.

APA

Jarden, J. O., Barry, D. I., Strandgaard, S., Graham, D. I., & Paulson, O. B. (1983). Cerebrovascular effects of the converting enzyme inhibitor captopril. Journal of Hypertension, 1(Suppl2), 126-8.

Vancouver

Jarden JO, Barry DI, Strandgaard S, Graham DI, Paulson OB. Cerebrovascular effects of the converting enzyme inhibitor captopril. Journal of Hypertension. 1983 dec.;1(Suppl2):126-8.

Author

Jarden, J O ; Barry, D I ; Strandgaard, S ; Graham, D I ; Paulson, O B. / Cerebrovascular effects of the converting enzyme inhibitor captopril. I: Journal of Hypertension. 1983 ; Bind 1, Nr. Suppl2. s. 126-8.

Bibtex

@article{36a7513af68040e795cd21d133c0ceda,
title = "Cerebrovascular effects of the converting enzyme inhibitor captopril",
abstract = "The effect of captopril on cerebral blood flow (CBF) and its autoregulation was studied in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Wistar rats. CBF was measured by the intracarotid 133Xe injection method. In one study 1 and 10 mg/kg captopril respectively were given intravenously to SHR and WKY. This caused the blood pressure to fall transiently below the lower blood pressure limit of CBF autoregulation; nonetheless CBF remained normal during captopril induced hypotension. In a second study it was shown with an integral uptake method that captopril is a very poor penetrator of the blood-brain barrier. In a third study captopril was instilled intracerebroventricularly in Wistar rats without any effect on CBF or its autoregulation. Thus when given intravenously, but not intracerebroventricularly captopril caused cerebral vasodilatation during acute hypotension.",
keywords = "Animals, Blood Pressure/drug effects, Blood-Brain Barrier, Captopril/metabolism, Cerebrovascular Circulation/drug effects, Homeostasis, Rats, Rats, Inbred SHR, Rats, Inbred Strains, Rats, Inbred WKY",
author = "Jarden, {J O} and Barry, {D I} and S Strandgaard and Graham, {D I} and Paulson, {O B}",
year = "1983",
month = dec,
language = "English",
volume = "1",
pages = "126--8",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "Suppl2",

}

RIS

TY - JOUR

T1 - Cerebrovascular effects of the converting enzyme inhibitor captopril

AU - Jarden, J O

AU - Barry, D I

AU - Strandgaard, S

AU - Graham, D I

AU - Paulson, O B

PY - 1983/12

Y1 - 1983/12

N2 - The effect of captopril on cerebral blood flow (CBF) and its autoregulation was studied in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Wistar rats. CBF was measured by the intracarotid 133Xe injection method. In one study 1 and 10 mg/kg captopril respectively were given intravenously to SHR and WKY. This caused the blood pressure to fall transiently below the lower blood pressure limit of CBF autoregulation; nonetheless CBF remained normal during captopril induced hypotension. In a second study it was shown with an integral uptake method that captopril is a very poor penetrator of the blood-brain barrier. In a third study captopril was instilled intracerebroventricularly in Wistar rats without any effect on CBF or its autoregulation. Thus when given intravenously, but not intracerebroventricularly captopril caused cerebral vasodilatation during acute hypotension.

AB - The effect of captopril on cerebral blood flow (CBF) and its autoregulation was studied in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Wistar rats. CBF was measured by the intracarotid 133Xe injection method. In one study 1 and 10 mg/kg captopril respectively were given intravenously to SHR and WKY. This caused the blood pressure to fall transiently below the lower blood pressure limit of CBF autoregulation; nonetheless CBF remained normal during captopril induced hypotension. In a second study it was shown with an integral uptake method that captopril is a very poor penetrator of the blood-brain barrier. In a third study captopril was instilled intracerebroventricularly in Wistar rats without any effect on CBF or its autoregulation. Thus when given intravenously, but not intracerebroventricularly captopril caused cerebral vasodilatation during acute hypotension.

KW - Animals

KW - Blood Pressure/drug effects

KW - Blood-Brain Barrier

KW - Captopril/metabolism

KW - Cerebrovascular Circulation/drug effects

KW - Homeostasis

KW - Rats

KW - Rats, Inbred SHR

KW - Rats, Inbred Strains

KW - Rats, Inbred WKY

M3 - Journal article

C2 - 6400112

VL - 1

SP - 126

EP - 128

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - Suppl2

ER -

ID: 279584735