Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset
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Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset. / Kornum, Birgitte Rahbek; Pizza, Fabio; Knudsen, Stine; Plazzi, Giuseppe; Jennum, Poul; Mignot, Emmanuel.
I: Brain, Behavior, and Immunity, Bind 49, 10.2015, s. 54-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset
AU - Kornum, Birgitte Rahbek
AU - Pizza, Fabio
AU - Knudsen, Stine
AU - Plazzi, Giuseppe
AU - Jennum, Poul
AU - Mignot, Emmanuel
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015/10
Y1 - 2015/10
N2 - Type 1 narcolepsy is caused by a loss of hypocretin (orexin) signaling in the brain. Genetic data suggests the disorder is caused by an autoimmune attack on hypocretin producing neurons in hypothalamus. This hypothesis has however not yet been confirmed by consistent findings of autoreactive antibodies or T-cells in patient samples. One explanation for these negative results may be that the autoimmune process is no longer active when patients present to the clinic. With increasing awareness in recent years, more and more patients have been diagnosed closer and closer to disease onset. In this study, we tested whether an active immune process in the brain could be detected in these patients, as reflected by increased cytokine levels in the cerebrospinal fluid (CSF). Using multiplex analysis, we measured the levels of 51 cytokines and chemokines in the CSF of 40 type 1 narcolepsy patients having varying disease duration. For comparison, we used samples from 9 healthy controls and 9 patients with other central hypersomnia. Cytokine levels did not differ significantly between controls and patients, even in 5 patients with disease onset less than a month prior to CSF sampling.
AB - Type 1 narcolepsy is caused by a loss of hypocretin (orexin) signaling in the brain. Genetic data suggests the disorder is caused by an autoimmune attack on hypocretin producing neurons in hypothalamus. This hypothesis has however not yet been confirmed by consistent findings of autoreactive antibodies or T-cells in patient samples. One explanation for these negative results may be that the autoimmune process is no longer active when patients present to the clinic. With increasing awareness in recent years, more and more patients have been diagnosed closer and closer to disease onset. In this study, we tested whether an active immune process in the brain could be detected in these patients, as reflected by increased cytokine levels in the cerebrospinal fluid (CSF). Using multiplex analysis, we measured the levels of 51 cytokines and chemokines in the CSF of 40 type 1 narcolepsy patients having varying disease duration. For comparison, we used samples from 9 healthy controls and 9 patients with other central hypersomnia. Cytokine levels did not differ significantly between controls and patients, even in 5 patients with disease onset less than a month prior to CSF sampling.
KW - Adolescent
KW - Adult
KW - Biomarkers
KW - Brain
KW - Child
KW - Cytokines
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Narcolepsy
KW - T-Lymphocytes, Helper-Inducer
KW - Young Adult
U2 - 10.1016/j.bbi.2015.03.004
DO - 10.1016/j.bbi.2015.03.004
M3 - Journal article
C2 - 25771509
VL - 49
SP - 54
EP - 58
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
ER -
ID: 162372340