Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder

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Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder. / Dalby, Rikke B.; Eskildsen, Simon F.; Videbech, Poul; Rosenberg, Raben; Østergaard, Leif.

I: Psychiatry Research - Neuroimaging, Bind 317, 111383, 2021, s. 1-10.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Dalby, RB, Eskildsen, SF, Videbech, P, Rosenberg, R & Østergaard, L 2021, 'Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder', Psychiatry Research - Neuroimaging, bind 317, 111383, s. 1-10. https://doi.org/10.1016/j.pscychresns.2021.111383

APA

Dalby, R. B., Eskildsen, S. F., Videbech, P., Rosenberg, R., & Østergaard, L. (2021). Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder. Psychiatry Research - Neuroimaging, 317, 1-10. [111383]. https://doi.org/10.1016/j.pscychresns.2021.111383

Vancouver

Dalby RB, Eskildsen SF, Videbech P, Rosenberg R, Østergaard L. Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder. Psychiatry Research - Neuroimaging. 2021;317:1-10. 111383. https://doi.org/10.1016/j.pscychresns.2021.111383

Author

Dalby, Rikke B. ; Eskildsen, Simon F. ; Videbech, Poul ; Rosenberg, Raben ; Østergaard, Leif. / Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder. I: Psychiatry Research - Neuroimaging. 2021 ; Bind 317. s. 1-10.

Bibtex

@article{02dc297c771148c2b30f42a54a9ab40a,
title = "Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder",
abstract = "In major depressive disorder (MDD), perfusion changes in cortico-limbic pathways are interpreted as altered neuronal activity, but they could also signify changes in neurovascular coupling due to altered capillary function. To examine capillary function in late-onset MDD, 22 patients and 22 age- and gender-matched controls underwent perfusion MRI. We measured normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), and relative transit-time heterogeneity (RTH). Resulting brain oxygenation was estimated in terms of oxygen tension and normalized metabolic rate of oxygen (nCMRO2). Patients revealed signs of capillary dysfunction (elevated RTH) in the anterior prefrontal cortex and ventral anterior cingulate cortex bilaterally and in the left insulate cortex compared to controls, bilateral hypometabolism (parallel reductions of nCBV, nCBF, and CMRO2) but preserved capillary function in the subthalamic nucleus and globus pallidus bilaterally, and hyperactivity with preserved capillary function (increased nCBF) in the cerebellum and brainstem. Our data support that perfusion changes in deep nuclei and cerebellum reflect abnormally low and high activity, respectively, in MDD patients, but suggest that microvascular pathology affects neurovascular coupling in ventral circuits. We speculate that microvascular pathology is important for our understanding of etiology of late-onset MDD as well as infererences about resulting brain activity changes.",
keywords = "Capillary dysfunction, Capillary transit time heterogeneity (CTH), Cerebral blood flow (CBF), Cerebral blood volume (CBV), Default mode network (DMN), Magnetic resonance imaging (MRI), Major depressive disorder (MDD), Neurovascular coupling, Relative transit time heterogeneity (RTH)",
author = "Dalby, {Rikke B.} and Eskildsen, {Simon F.} and Poul Videbech and Raben Rosenberg and Leif {\O}stergaard",
note = "Publisher Copyright: {\textcopyright} 2021",
year = "2021",
doi = "10.1016/j.pscychresns.2021.111383",
language = "English",
volume = "317",
pages = "1--10",
journal = "Psychiatry Research: Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder

AU - Dalby, Rikke B.

AU - Eskildsen, Simon F.

AU - Videbech, Poul

AU - Rosenberg, Raben

AU - Østergaard, Leif

N1 - Publisher Copyright: © 2021

PY - 2021

Y1 - 2021

N2 - In major depressive disorder (MDD), perfusion changes in cortico-limbic pathways are interpreted as altered neuronal activity, but they could also signify changes in neurovascular coupling due to altered capillary function. To examine capillary function in late-onset MDD, 22 patients and 22 age- and gender-matched controls underwent perfusion MRI. We measured normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), and relative transit-time heterogeneity (RTH). Resulting brain oxygenation was estimated in terms of oxygen tension and normalized metabolic rate of oxygen (nCMRO2). Patients revealed signs of capillary dysfunction (elevated RTH) in the anterior prefrontal cortex and ventral anterior cingulate cortex bilaterally and in the left insulate cortex compared to controls, bilateral hypometabolism (parallel reductions of nCBV, nCBF, and CMRO2) but preserved capillary function in the subthalamic nucleus and globus pallidus bilaterally, and hyperactivity with preserved capillary function (increased nCBF) in the cerebellum and brainstem. Our data support that perfusion changes in deep nuclei and cerebellum reflect abnormally low and high activity, respectively, in MDD patients, but suggest that microvascular pathology affects neurovascular coupling in ventral circuits. We speculate that microvascular pathology is important for our understanding of etiology of late-onset MDD as well as infererences about resulting brain activity changes.

AB - In major depressive disorder (MDD), perfusion changes in cortico-limbic pathways are interpreted as altered neuronal activity, but they could also signify changes in neurovascular coupling due to altered capillary function. To examine capillary function in late-onset MDD, 22 patients and 22 age- and gender-matched controls underwent perfusion MRI. We measured normalized cerebral blood flow (nCBF), cerebral blood volume (nCBV), and relative transit-time heterogeneity (RTH). Resulting brain oxygenation was estimated in terms of oxygen tension and normalized metabolic rate of oxygen (nCMRO2). Patients revealed signs of capillary dysfunction (elevated RTH) in the anterior prefrontal cortex and ventral anterior cingulate cortex bilaterally and in the left insulate cortex compared to controls, bilateral hypometabolism (parallel reductions of nCBV, nCBF, and CMRO2) but preserved capillary function in the subthalamic nucleus and globus pallidus bilaterally, and hyperactivity with preserved capillary function (increased nCBF) in the cerebellum and brainstem. Our data support that perfusion changes in deep nuclei and cerebellum reflect abnormally low and high activity, respectively, in MDD patients, but suggest that microvascular pathology affects neurovascular coupling in ventral circuits. We speculate that microvascular pathology is important for our understanding of etiology of late-onset MDD as well as infererences about resulting brain activity changes.

KW - Capillary dysfunction

KW - Capillary transit time heterogeneity (CTH)

KW - Cerebral blood flow (CBF)

KW - Cerebral blood volume (CBV)

KW - Default mode network (DMN)

KW - Magnetic resonance imaging (MRI)

KW - Major depressive disorder (MDD)

KW - Neurovascular coupling

KW - Relative transit time heterogeneity (RTH)

UR - http://www.scopus.com/inward/record.url?scp=85114612404&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2021.111383

DO - 10.1016/j.pscychresns.2021.111383

M3 - Journal article

C2 - 34508953

AN - SCOPUS:85114612404

VL - 317

SP - 1

EP - 10

JO - Psychiatry Research: Neuroimaging

JF - Psychiatry Research: Neuroimaging

SN - 0925-4927

M1 - 111383

ER -

ID: 304369692