Central and peripheral hemodynamics in exercising humans: leg vs arm exercise
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Central and peripheral hemodynamics in exercising humans : leg vs arm exercise. / Calbet, J A L; González-Alonso, J; Helge, J W; Søndergaard, H; Munch-Andersen, T; Saltin, B; Boushel, R.
I: Scandinavian Journal of Medicine & Science in Sports, Bind 25, Nr. Suppl 4, 2015, s. 144-157.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Central and peripheral hemodynamics in exercising humans
T2 - leg vs arm exercise
AU - Calbet, J A L
AU - González-Alonso, J
AU - Helge, J W
AU - Søndergaard, H
AU - Munch-Andersen, T
AU - Saltin, B
AU - Boushel, R
N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2015
Y1 - 2015
N2 - In humans, arm exercise is known to elicit larger increases in arterial blood pressure (BP) than leg exercise. However, the precise regulation of regional vascular conductances (VC) for the distribution of cardiac output with exercise intensity remains unknown. Hemodynamic responses were assessed during incremental upright arm cranking (AC) and leg pedalling (LP) to exhaustion (Wmax) in nine males. Systemic VC, peak cardiac output (Qpeak) (indocyanine green) and stroke volume (SV) were 18%, 23%, and 20% lower during AC than LP. The mean BP, the rate-pressure product and the associated myocardial oxygen demand were 22%, 12%, and 14% higher, respectively, during maximal AC than LP. Trunk VC was reduced to similar values at Wmax. At Wmax, muscle mass-normalized VC and fractional O2 extraction were lower in the arm than the leg muscles. However, this was compensated for during AC by raising perfusion pressure to increase O2 delivery, allowing a similar peak VO2 per kg of muscle mass in both extremities. In summary, despite a lower Qpeak during arm cranking the cardiovascular strain is much higher than during leg pedalling. The adjustments of regional conductances during incremental exercise to exhaustion depend mostly on the relative intensity of exercise and are limb-specific.
AB - In humans, arm exercise is known to elicit larger increases in arterial blood pressure (BP) than leg exercise. However, the precise regulation of regional vascular conductances (VC) for the distribution of cardiac output with exercise intensity remains unknown. Hemodynamic responses were assessed during incremental upright arm cranking (AC) and leg pedalling (LP) to exhaustion (Wmax) in nine males. Systemic VC, peak cardiac output (Qpeak) (indocyanine green) and stroke volume (SV) were 18%, 23%, and 20% lower during AC than LP. The mean BP, the rate-pressure product and the associated myocardial oxygen demand were 22%, 12%, and 14% higher, respectively, during maximal AC than LP. Trunk VC was reduced to similar values at Wmax. At Wmax, muscle mass-normalized VC and fractional O2 extraction were lower in the arm than the leg muscles. However, this was compensated for during AC by raising perfusion pressure to increase O2 delivery, allowing a similar peak VO2 per kg of muscle mass in both extremities. In summary, despite a lower Qpeak during arm cranking the cardiovascular strain is much higher than during leg pedalling. The adjustments of regional conductances during incremental exercise to exhaustion depend mostly on the relative intensity of exercise and are limb-specific.
KW - Adult
KW - Arm
KW - Arterial Pressure
KW - Exercise
KW - Exercise Test
KW - Heart
KW - Hemodynamics
KW - Humans
KW - Leg
KW - Male
KW - Middle Aged
KW - Muscle, Skeletal
KW - Oxygen
KW - Physical Exertion
KW - Regional Blood Flow
KW - Stroke Volume
KW - Vascular Resistance
KW - Young Adult
KW - Comparative Study
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/sms.12604
DO - 10.1111/sms.12604
M3 - Journal article
C2 - 26589128
VL - 25
SP - 144
EP - 157
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - Suppl 4
ER -
ID: 184740475