cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders
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cCOG : A web-based cognitive test tool for detecting neurodegenerative disorders. / Rhodius-Meester, Hanneke F M; Paajanen, Teemu; Koikkalainen, Juha; Mahdiani, Shadi; Bruun, Marie; Baroni, Marta; Lemstra, Afina W; Scheltens, Philip; Herukka, Sanna-Kaisa; Pikkarainen, Maria; Hall, Anette; Hänninen, Tuomo; Ngandu, Tiia; Kivipelto, Miia; van Gils, Mark; Hasselbalch, Steen Gregers; Mecocci, Patrizia; Remes, Anne; Soininen, Hilkka; van der Flier, Wiesje M; Lötjönen, Jyrki.
I: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Bind 12, Nr. 1, e12083, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - cCOG
T2 - A web-based cognitive test tool for detecting neurodegenerative disorders
AU - Rhodius-Meester, Hanneke F M
AU - Paajanen, Teemu
AU - Koikkalainen, Juha
AU - Mahdiani, Shadi
AU - Bruun, Marie
AU - Baroni, Marta
AU - Lemstra, Afina W
AU - Scheltens, Philip
AU - Herukka, Sanna-Kaisa
AU - Pikkarainen, Maria
AU - Hall, Anette
AU - Hänninen, Tuomo
AU - Ngandu, Tiia
AU - Kivipelto, Miia
AU - van Gils, Mark
AU - Hasselbalch, Steen Gregers
AU - Mecocci, Patrizia
AU - Remes, Anne
AU - Soininen, Hilkka
AU - van der Flier, Wiesje M
AU - Lötjönen, Jyrki
N1 - © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
PY - 2020
Y1 - 2020
N2 - Introduction: Web-based cognitive tests have potential for standardized screening in neurodegenerative disorders. We examined accuracy and consistency of cCOG, a computerized cognitive tool, in detecting mild cognitive impairment (MCI) and dementia.Methods: Clinical data of 306 cognitively normal, 120 mild cognitive impairment (MCI), and 69 dementia subjects from three European cohorts were analyzed. Global cognitive score was defined from standard neuropsychological tests and compared to the corresponding estimated score from the cCOG tool containing seven subtasks. The consistency of cCOG was assessed comparing measurements administered in clinical settings and in the home environment.Results: cCOG produced accuracies (receiver operating characteristic-area under the curve [ROC-AUC]) between 0.71 and 0.84 in detecting MCI and 0.86 and 0.94 in detecting dementia when administered at the clinic and at home. The accuracy was comparable to the results of standard neuropsychological tests (AUC 0.69-0.77 MCI/0.91-0.92 dementia).Discussion: cCOG provides a promising tool for detecting MCI and dementia with potential for a cost-effective approach including home-based cognitive assessments.
AB - Introduction: Web-based cognitive tests have potential for standardized screening in neurodegenerative disorders. We examined accuracy and consistency of cCOG, a computerized cognitive tool, in detecting mild cognitive impairment (MCI) and dementia.Methods: Clinical data of 306 cognitively normal, 120 mild cognitive impairment (MCI), and 69 dementia subjects from three European cohorts were analyzed. Global cognitive score was defined from standard neuropsychological tests and compared to the corresponding estimated score from the cCOG tool containing seven subtasks. The consistency of cCOG was assessed comparing measurements administered in clinical settings and in the home environment.Results: cCOG produced accuracies (receiver operating characteristic-area under the curve [ROC-AUC]) between 0.71 and 0.84 in detecting MCI and 0.86 and 0.94 in detecting dementia when administered at the clinic and at home. The accuracy was comparable to the results of standard neuropsychological tests (AUC 0.69-0.77 MCI/0.91-0.92 dementia).Discussion: cCOG provides a promising tool for detecting MCI and dementia with potential for a cost-effective approach including home-based cognitive assessments.
U2 - 10.1002/dad2.12083
DO - 10.1002/dad2.12083
M3 - Journal article
C2 - 32864411
VL - 12
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
SN - 2352-8729
IS - 1
M1 - e12083
ER -
ID: 253399194