Cardiovascular risk prediction in the general population with use of suPAR, CRP, and Framingham Risk Score
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Cardiovascular risk prediction in the general population with use of suPAR, CRP, and Framingham Risk Score. / Lyngbæk, Stig; Marott, Jacob L; Sehestedt, Thomas; Hansen, Tine W; Olsen, Michael H; Andersen, Ove; Linneberg, Allan; Haugaard, Steen B; Eugen-Olsen, Jesper; Hansen, Peter R; Jeppesen, Jørgen.
I: International Journal of Cardiology, Bind 167, Nr. 6, 09.2013, s. 2904-11.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cardiovascular risk prediction in the general population with use of suPAR, CRP, and Framingham Risk Score
AU - Lyngbæk, Stig
AU - Marott, Jacob L
AU - Sehestedt, Thomas
AU - Hansen, Tine W
AU - Olsen, Michael H
AU - Andersen, Ove
AU - Linneberg, Allan
AU - Haugaard, Steen B
AU - Eugen-Olsen, Jesper
AU - Hansen, Peter R
AU - Jeppesen, Jørgen
N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PY - 2013/9
Y1 - 2013/9
N2 - BACKGROUND: The inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR) and C-reactive protein (CRP) independently predict cardiovascular disease (CVD). The prognostic implications of suPAR and CRP combined with Framingham Risk Score (FRS) have not been determined. METHODS: From 1993 to 1994, baseline levels of suPAR and CRP were obtained from 2315 generally healthy Danish individuals (mean [SD] age: 53.9 [10.6] years) who were followed for the composite outcome of ischemic heart disease, stroke and CVD mortality. RESULTS: During a median follow-up of 12.7years, 302 events were recorded. After adjusting for FRS, women with suPAR levels in the highest tertile had a 1.74-fold (95% confidence interval [CI]: 1.08-2.81, p=0.027) and men a 2.09-fold (95% CI: 1.37-3.18, p20%) risk categories, respectively. This was reflected in a significant improvement of C statistics for men (p=0.034) and borderline significant for women (p=0.054), while the integrated discrimination improvement was highly significant (P≤0.001) for both genders. CONCLUSIONS: suPAR provides prognostic information of CVD risk beyond FRS and improves risk prediction substantially when combined with CRP in this setting.
AB - BACKGROUND: The inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR) and C-reactive protein (CRP) independently predict cardiovascular disease (CVD). The prognostic implications of suPAR and CRP combined with Framingham Risk Score (FRS) have not been determined. METHODS: From 1993 to 1994, baseline levels of suPAR and CRP were obtained from 2315 generally healthy Danish individuals (mean [SD] age: 53.9 [10.6] years) who were followed for the composite outcome of ischemic heart disease, stroke and CVD mortality. RESULTS: During a median follow-up of 12.7years, 302 events were recorded. After adjusting for FRS, women with suPAR levels in the highest tertile had a 1.74-fold (95% confidence interval [CI]: 1.08-2.81, p=0.027) and men a 2.09-fold (95% CI: 1.37-3.18, p20%) risk categories, respectively. This was reflected in a significant improvement of C statistics for men (p=0.034) and borderline significant for women (p=0.054), while the integrated discrimination improvement was highly significant (P≤0.001) for both genders. CONCLUSIONS: suPAR provides prognostic information of CVD risk beyond FRS and improves risk prediction substantially when combined with CRP in this setting.
U2 - 10.1016/j.ijcard.2012.07.018
DO - 10.1016/j.ijcard.2012.07.018
M3 - Journal article
C2 - 22909410
VL - 167
SP - 2904
EP - 2911
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 6
ER -
ID: 48417944