Cardiac findings in newborn twins

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Cardiac findings in newborn twins. / Molin, Julie; Paerregaard, Maria Munk; Pihl, Christian; Thygesen, Caroline Boye; Pietersen, Adrian; Dannesbo, Sofie; Norsk, Jakob Boesgaard; Raja, Anna Axelsson; Vøgg, Ruth Ottilia B; Sillesen, Anne-Sophie; Iversen, Kasper Karmark; Bundgaard, Henning; Christensen, Alex Hørby.

I: Acta Paediatrica, Bind 112, Nr. 10, 2023, s. 2050-2059.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Molin, J, Paerregaard, MM, Pihl, C, Thygesen, CB, Pietersen, A, Dannesbo, S, Norsk, JB, Raja, AA, Vøgg, ROB, Sillesen, A-S, Iversen, KK, Bundgaard, H & Christensen, AH 2023, 'Cardiac findings in newborn twins', Acta Paediatrica, bind 112, nr. 10, s. 2050-2059. https://doi.org/10.1111/apa.16626

APA

Molin, J., Paerregaard, M. M., Pihl, C., Thygesen, C. B., Pietersen, A., Dannesbo, S., Norsk, J. B., Raja, A. A., Vøgg, R. O. B., Sillesen, A-S., Iversen, K. K., Bundgaard, H., & Christensen, A. H. (2023). Cardiac findings in newborn twins. Acta Paediatrica, 112(10), 2050-2059. https://doi.org/10.1111/apa.16626

Vancouver

Molin J, Paerregaard MM, Pihl C, Thygesen CB, Pietersen A, Dannesbo S o.a. Cardiac findings in newborn twins. Acta Paediatrica. 2023;112(10):2050-2059. https://doi.org/10.1111/apa.16626

Author

Molin, Julie ; Paerregaard, Maria Munk ; Pihl, Christian ; Thygesen, Caroline Boye ; Pietersen, Adrian ; Dannesbo, Sofie ; Norsk, Jakob Boesgaard ; Raja, Anna Axelsson ; Vøgg, Ruth Ottilia B ; Sillesen, Anne-Sophie ; Iversen, Kasper Karmark ; Bundgaard, Henning ; Christensen, Alex Hørby. / Cardiac findings in newborn twins. I: Acta Paediatrica. 2023 ; Bind 112, Nr. 10. s. 2050-2059.

Bibtex

@article{4f205a80d1164dcc97c3469362a4c866,

title = "Cardiac findings in newborn twins",

abstract = "AIMS: To evaluate cardiac findings in newborn twins from the general population and investigate if newborn twins may require systematic evaluation of cardiac parameters.METHODS: Prospective cohort study of newborns with cardiac evaluation performed during the first month of life. Cardiac findings were compared 1:3 with matched singletons.RESULTS: We included 412 newborn twins (16% monochorionic; 50% boys) and 1236 singletons. Comparing cardiac findings showed twins had an increased prevalence of non-severe structural heart disease (most common: ventricular septal defects in both groups), thinner left ventricular posterior wall in diastole (LVPWd; 1.82 vs. 1.87 mm, p = 0.02), smaller diameter of the left atrium (10.6 vs. 11.1 mm, p = 0.04), higher heart rate (148 vs. 144 bpm, p = 0.04), more left-shifted QRS axis (106 vs. 111°, p < 0.001), and lower maximum R-wave amplitude in V1 (927 vs. 1015 μV, p = 0.02) compared to singletons. After multifactorial adjustment for potential confounders, the effect of twinning on cardiac parameters persisted only for LVPWd (p < 0.05).CONCLUSION: Despite contemporary surveillance, we found an increased prevalence of non-severe structural heart disease in a population-based cohort of newborn twins. However, the effect of twinning on cardiac parameters was modest and generally did not persist after correction for likely confounding factors.",

author = "Julie Molin and Paerregaard, {Maria Munk} and Christian Pihl and Thygesen, {Caroline Boye} and Adrian Pietersen and Sofie Dannesbo and Norsk, {Jakob Boesgaard} and Raja, {Anna Axelsson} and V{\o}gg, {Ruth Ottilia B} and Anne-Sophie Sillesen and Iversen, {Kasper Karmark} and Henning Bundgaard and Christensen, {Alex H{\o}rby}",

note = "{\textcopyright} 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.",

year = "2023",

doi = "10.1111/apa.16626",

language = "English",

volume = "112",

pages = "2050--2059",

journal = "Acta Paediatrica",

issn = "0803-5253",

publisher = "Wiley-Blackwell",

number = "10",

}

RIS

TY - JOUR

T1 - Cardiac findings in newborn twins

AU - Molin, Julie

AU - Paerregaard, Maria Munk

AU - Pihl, Christian

AU - Thygesen, Caroline Boye

AU - Pietersen, Adrian

AU - Dannesbo, Sofie

AU - Norsk, Jakob Boesgaard

AU - Raja, Anna Axelsson

AU - Vøgg, Ruth Ottilia B

AU - Sillesen, Anne-Sophie

AU - Iversen, Kasper Karmark

AU - Bundgaard, Henning

AU - Christensen, Alex Hørby

PY - 2023

Y1 - 2023

N2 - AIMS: To evaluate cardiac findings in newborn twins from the general population and investigate if newborn twins may require systematic evaluation of cardiac parameters.METHODS: Prospective cohort study of newborns with cardiac evaluation performed during the first month of life. Cardiac findings were compared 1:3 with matched singletons.RESULTS: We included 412 newborn twins (16% monochorionic; 50% boys) and 1236 singletons. Comparing cardiac findings showed twins had an increased prevalence of non-severe structural heart disease (most common: ventricular septal defects in both groups), thinner left ventricular posterior wall in diastole (LVPWd; 1.82 vs. 1.87 mm, p = 0.02), smaller diameter of the left atrium (10.6 vs. 11.1 mm, p = 0.04), higher heart rate (148 vs. 144 bpm, p = 0.04), more left-shifted QRS axis (106 vs. 111°, p < 0.001), and lower maximum R-wave amplitude in V1 (927 vs. 1015 μV, p = 0.02) compared to singletons. After multifactorial adjustment for potential confounders, the effect of twinning on cardiac parameters persisted only for LVPWd (p < 0.05).CONCLUSION: Despite contemporary surveillance, we found an increased prevalence of non-severe structural heart disease in a population-based cohort of newborn twins. However, the effect of twinning on cardiac parameters was modest and generally did not persist after correction for likely confounding factors.

AB - AIMS: To evaluate cardiac findings in newborn twins from the general population and investigate if newborn twins may require systematic evaluation of cardiac parameters.METHODS: Prospective cohort study of newborns with cardiac evaluation performed during the first month of life. Cardiac findings were compared 1:3 with matched singletons.RESULTS: We included 412 newborn twins (16% monochorionic; 50% boys) and 1236 singletons. Comparing cardiac findings showed twins had an increased prevalence of non-severe structural heart disease (most common: ventricular septal defects in both groups), thinner left ventricular posterior wall in diastole (LVPWd; 1.82 vs. 1.87 mm, p = 0.02), smaller diameter of the left atrium (10.6 vs. 11.1 mm, p = 0.04), higher heart rate (148 vs. 144 bpm, p = 0.04), more left-shifted QRS axis (106 vs. 111°, p < 0.001), and lower maximum R-wave amplitude in V1 (927 vs. 1015 μV, p = 0.02) compared to singletons. After multifactorial adjustment for potential confounders, the effect of twinning on cardiac parameters persisted only for LVPWd (p < 0.05).CONCLUSION: Despite contemporary surveillance, we found an increased prevalence of non-severe structural heart disease in a population-based cohort of newborn twins. However, the effect of twinning on cardiac parameters was modest and generally did not persist after correction for likely confounding factors.

U2 - 10.1111/apa.16626

DO - 10.1111/apa.16626

M3 - Journal article

C2 - 36513612

VL - 112

SP - 2050

EP - 2059

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 10

ER -

ID: 331252061