Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura
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Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura. / Ghanizada, Hashmat; Arngrim, Nanna; Schytz, Henrik Winther; Olesen, Jes; Ashina, Messoud.
I: Cephalalgia, Bind 38, Nr. 13, 01.11.2018, s. 1940-1949.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Carbon monoxide inhalation induces headache but no migraine in patients with migraine without aura
AU - Ghanizada, Hashmat
AU - Arngrim, Nanna
AU - Schytz, Henrik Winther
AU - Olesen, Jes
AU - Ashina, Messoud
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Introduction: Carbon monoxide is an endogenously produced signaling gasotransmitter known to cause headache and vasodilation. We hypothesized that inhalation of carbon monoxide would induce migraine-like attacks in migraine without aura patients. Methods: In a randomized, double-blind, placebo-controlled crossover design, 12 migraine patients were allocated to inhalation of carbon monoxide (carboxyhemoglobin 22%) or placebo on two separate days. Headache and migraine characteristics were recorded during hospital (0–2 hours) and post-hospital (2–13 hours) phases. Results: Six patients (50%) developed migraine-like attacks after carbon monoxide compared to two after placebo (16.7%) (p = 0.289). The median time to onset of migraine-like attacks after carbon monoxide inhalation was 7.5 h (range 3–12) compared to 11.5 h (range 11–12) after placebo. Nine out of 12 patients (75%) developed prolonged headache after carbon monoxide. The area under the curve for headache score (0–13 hours) was increased after carbon monoxide compared with placebo (p = 0.033). Conclusion: Carbon monoxide inhalation did not provoke more migraine-like attacks in migraine patients compared to placebo, but induced more headache in patients compared to placebo. These data suggest that non-toxic concentrations of carbon monoxide had low potency in migraine induction and that the carbon monoxide inhalation model is not suitable to study migraine.
AB - Introduction: Carbon monoxide is an endogenously produced signaling gasotransmitter known to cause headache and vasodilation. We hypothesized that inhalation of carbon monoxide would induce migraine-like attacks in migraine without aura patients. Methods: In a randomized, double-blind, placebo-controlled crossover design, 12 migraine patients were allocated to inhalation of carbon monoxide (carboxyhemoglobin 22%) or placebo on two separate days. Headache and migraine characteristics were recorded during hospital (0–2 hours) and post-hospital (2–13 hours) phases. Results: Six patients (50%) developed migraine-like attacks after carbon monoxide compared to two after placebo (16.7%) (p = 0.289). The median time to onset of migraine-like attacks after carbon monoxide inhalation was 7.5 h (range 3–12) compared to 11.5 h (range 11–12) after placebo. Nine out of 12 patients (75%) developed prolonged headache after carbon monoxide. The area under the curve for headache score (0–13 hours) was increased after carbon monoxide compared with placebo (p = 0.033). Conclusion: Carbon monoxide inhalation did not provoke more migraine-like attacks in migraine patients compared to placebo, but induced more headache in patients compared to placebo. These data suggest that non-toxic concentrations of carbon monoxide had low potency in migraine induction and that the carbon monoxide inhalation model is not suitable to study migraine.
KW - Carbon monoxide
KW - gasotransmitter
KW - hypoxia
KW - migraine
KW - nitric oxide
UR - http://www.scopus.com/inward/record.url?scp=85044028031&partnerID=8YFLogxK
U2 - 10.1177/0333102418765771
DO - 10.1177/0333102418765771
M3 - Journal article
C2 - 29540069
AN - SCOPUS:85044028031
VL - 38
SP - 1940
EP - 1949
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 13
ER -
ID: 221260200