Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
Standard
Canine induced pluripotent stem cells : An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease. / De Figueiredo Pessôa, Laís Vicari; Chandrasekaran, Abinaya; Thomsen, Barbara Blicher; Berendt, Mette; Hyttel, Poul; Freude, Kristine.
iPSCs from Diverse Species. Academic Press, 2020. s. 77-91.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - CHAP
T1 - Canine induced pluripotent stem cells
T2 - An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease
AU - De Figueiredo Pessôa, Laís Vicari
AU - Chandrasekaran, Abinaya
AU - Thomsen, Barbara Blicher
AU - Berendt, Mette
AU - Hyttel, Poul
AU - Freude, Kristine
N1 - Publisher Copyright: © 2021 Elsevier Inc. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Canine cognitive dysfunction (CCD) is a potential natural model for human Alzheimer’s disease (AD). In this chapter we are addressing the current procedures of how to obtain canine induced pluripotent stem cells (ciPSCs) from geriatric dogs and the available protocols for differentiation of ciPSC into neurons. Moreover, we present how these neurons derived from ciPSC can be compared to human iPSC (hiPSC)-derived neurons in order to validate dogs with CCD as natural models for AD. This practical example presents the importance to generate species-specific iPSC to broaden our knowledge of cell type-specific disease models and to investigate, compare, and evaluate the different animal models as appropriate disease models for human diseases.
AB - Canine cognitive dysfunction (CCD) is a potential natural model for human Alzheimer’s disease (AD). In this chapter we are addressing the current procedures of how to obtain canine induced pluripotent stem cells (ciPSCs) from geriatric dogs and the available protocols for differentiation of ciPSC into neurons. Moreover, we present how these neurons derived from ciPSC can be compared to human iPSC (hiPSC)-derived neurons in order to validate dogs with CCD as natural models for AD. This practical example presents the importance to generate species-specific iPSC to broaden our knowledge of cell type-specific disease models and to investigate, compare, and evaluate the different animal models as appropriate disease models for human diseases.
KW - Cellular
KW - Clinical trial
KW - Cognitive dysfunction
KW - Comparative study
KW - Dementia
KW - Development
KW - Differentiation
KW - Disease model
KW - Dog
KW - Drugs
KW - Fibroblast
KW - iPSC
KW - Neural induction
KW - Pluripotency
KW - Progenitor cells
KW - Reprogramming
U2 - 10.1016/B978-0-12-822228-7.00010-2
DO - 10.1016/B978-0-12-822228-7.00010-2
M3 - Book chapter
AN - SCOPUS:85147601464
SP - 77
EP - 91
BT - iPSCs from Diverse Species
PB - Academic Press
ER -
ID: 337997274