Standard
Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. / Peterlongo, Paolo; Chang-Claude, Jenny; Moysich, Kirsten B; Rudolph, Anja; Schmutzler, Rita K; Simard, Jacques; Soucy, Penny; Eeles, Rosalind A; Easton, Douglas F; Hamann, Ute; Wilkening, Stefan; Chen, Bowang; Rookus, Matti A; Schmidt, Marjanka K; van der Baan, Frederieke H; Spurdle, Amanda B; Walker, Logan C; Lose, Felicity; Maia, Ana-Teresa; Montagna, Marco; Matricardi, Laura; Lubinski, Jan; Jakubowska, Anna; Gómez Garcia, Encarna B; Olopade, Olufunmilayo I; Nussbaum, Robert L; Nathanson, Katherine L; Domchek, Susan M; Rebbeck, Timothy R; Arun, Banu K; Karlan, Beth Y; Orsulic, Sandra; Lester, Jenny; Chung, Wendy K; Miron, Alex; Southey, Melissa C; Goldgar, David E; Buys, Saundra S; Janavicius, Ramunas; Dorfling, Cecilia M; van Rensburg, Elizabeth J; Ding, Yuan Chun; Neuhausen, Susan L; Hansen, Thomas v. O.; Gerdes, Anne-Marie; Ejlertsen, Bent; Jønson, Lars; Osorio, Ana; Martínez-Bouzas, Cristina; Benitez, Javier; EMBRACE.
I:
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Bind 24, Nr. 1, 01.2015, s. 308-16.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Peterlongo, P, Chang-Claude, J, Moysich, KB, Rudolph, A, Schmutzler, RK, Simard, J, Soucy, P, Eeles, RA, Easton, DF, Hamann, U, Wilkening, S, Chen, B, Rookus, MA, Schmidt, MK, van der Baan, FH, Spurdle, AB, Walker, LC, Lose, F, Maia, A-T, Montagna, M, Matricardi, L, Lubinski, J, Jakubowska, A, Gómez Garcia, EB, Olopade, OI, Nussbaum, RL, Nathanson, KL, Domchek, SM, Rebbeck, TR, Arun, BK, Karlan, BY, Orsulic, S, Lester, J, Chung, WK, Miron, A, Southey, MC, Goldgar, DE, Buys, SS, Janavicius, R, Dorfling, CM, van Rensburg, EJ, Ding, YC, Neuhausen, SL, Hansen, TVO
, Gerdes, A-M, Ejlertsen, B, Jønson, L, Osorio, A, Martínez-Bouzas, C, Benitez, J & EMBRACE 2015, '
Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers',
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, bind 24, nr. 1, s. 308-16.
https://doi.org/10.1158/1055-9965.EPI-14-0532
APA
Peterlongo, P., Chang-Claude, J., Moysich, K. B., Rudolph, A., Schmutzler, R. K., Simard, J., Soucy, P., Eeles, R. A., Easton, D. F., Hamann, U., Wilkening, S., Chen, B., Rookus, M. A., Schmidt, M. K., van der Baan, F. H., Spurdle, A. B., Walker, L. C., Lose, F., Maia, A-T., ... EMBRACE (2015).
Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
24(1), 308-16.
https://doi.org/10.1158/1055-9965.EPI-14-0532
Vancouver
Peterlongo P, Chang-Claude J, Moysich KB, Rudolph A, Schmutzler RK, Simard J o.a.
Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015 jan.;24(1):308-16.
https://doi.org/10.1158/1055-9965.EPI-14-0532
Author
Peterlongo, Paolo ; Chang-Claude, Jenny ; Moysich, Kirsten B ; Rudolph, Anja ; Schmutzler, Rita K ; Simard, Jacques ; Soucy, Penny ; Eeles, Rosalind A ; Easton, Douglas F ; Hamann, Ute ; Wilkening, Stefan ; Chen, Bowang ; Rookus, Matti A ; Schmidt, Marjanka K ; van der Baan, Frederieke H ; Spurdle, Amanda B ; Walker, Logan C ; Lose, Felicity ; Maia, Ana-Teresa ; Montagna, Marco ; Matricardi, Laura ; Lubinski, Jan ; Jakubowska, Anna ; Gómez Garcia, Encarna B ; Olopade, Olufunmilayo I ; Nussbaum, Robert L ; Nathanson, Katherine L ; Domchek, Susan M ; Rebbeck, Timothy R ; Arun, Banu K ; Karlan, Beth Y ; Orsulic, Sandra ; Lester, Jenny ; Chung, Wendy K ; Miron, Alex ; Southey, Melissa C ; Goldgar, David E ; Buys, Saundra S ; Janavicius, Ramunas ; Dorfling, Cecilia M ; van Rensburg, Elizabeth J ; Ding, Yuan Chun ; Neuhausen, Susan L ; Hansen, Thomas v. O. ; Gerdes, Anne-Marie ; Ejlertsen, Bent ; Jønson, Lars ; Osorio, Ana ; Martínez-Bouzas, Cristina ; Benitez, Javier ; EMBRACE. / Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015 ; Bind 24, Nr. 1. s. 308-16.
Bibtex
@article{539ad2e8c17b4c41b020564446968ea7,
title = "Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers",
abstract = "BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.METHODS: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.RESULTS: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.CONCLUSION: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.IMPACT: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies.",
keywords = "Adult, Breast Neoplasms, Cohort Studies, Female, Genes, BRCA1, Genes, BRCA2, Humans, Mutation, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Retrospective Studies, Young Adult",
author = "Paolo Peterlongo and Jenny Chang-Claude and Moysich, {Kirsten B} and Anja Rudolph and Schmutzler, {Rita K} and Jacques Simard and Penny Soucy and Eeles, {Rosalind A} and Easton, {Douglas F} and Ute Hamann and Stefan Wilkening and Bowang Chen and Rookus, {Matti A} and Schmidt, {Marjanka K} and {van der Baan}, {Frederieke H} and Spurdle, {Amanda B} and Walker, {Logan C} and Felicity Lose and Ana-Teresa Maia and Marco Montagna and Laura Matricardi and Jan Lubinski and Anna Jakubowska and {G{\'o}mez Garcia}, {Encarna B} and Olopade, {Olufunmilayo I} and Nussbaum, {Robert L} and Nathanson, {Katherine L} and Domchek, {Susan M} and Rebbeck, {Timothy R} and Arun, {Banu K} and Karlan, {Beth Y} and Sandra Orsulic and Jenny Lester and Chung, {Wendy K} and Alex Miron and Southey, {Melissa C} and Goldgar, {David E} and Buys, {Saundra S} and Ramunas Janavicius and Dorfling, {Cecilia M} and {van Rensburg}, {Elizabeth J} and Ding, {Yuan Chun} and Neuhausen, {Susan L} and Hansen, {Thomas v. O.} and Anne-Marie Gerdes and Bent Ejlertsen and Lars J{\o}nson and Ana Osorio and Cristina Mart{\'i}nez-Bouzas and Javier Benitez and EMBRACE",
note = "{\textcopyright}2014 American Association for Cancer Research.",
year = "2015",
month = jan,
doi = "10.1158/1055-9965.EPI-14-0532",
language = "English",
volume = "24",
pages = "308--16",
journal = "Cancer Epidemiology, Biomarkers & Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research (A A C R)",
number = "1",
}
RIS
TY - JOUR
T1 - Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers
AU - Peterlongo, Paolo
AU - Chang-Claude, Jenny
AU - Moysich, Kirsten B
AU - Rudolph, Anja
AU - Schmutzler, Rita K
AU - Simard, Jacques
AU - Soucy, Penny
AU - Eeles, Rosalind A
AU - Easton, Douglas F
AU - Hamann, Ute
AU - Wilkening, Stefan
AU - Chen, Bowang
AU - Rookus, Matti A
AU - Schmidt, Marjanka K
AU - van der Baan, Frederieke H
AU - Spurdle, Amanda B
AU - Walker, Logan C
AU - Lose, Felicity
AU - Maia, Ana-Teresa
AU - Montagna, Marco
AU - Matricardi, Laura
AU - Lubinski, Jan
AU - Jakubowska, Anna
AU - Gómez Garcia, Encarna B
AU - Olopade, Olufunmilayo I
AU - Nussbaum, Robert L
AU - Nathanson, Katherine L
AU - Domchek, Susan M
AU - Rebbeck, Timothy R
AU - Arun, Banu K
AU - Karlan, Beth Y
AU - Orsulic, Sandra
AU - Lester, Jenny
AU - Chung, Wendy K
AU - Miron, Alex
AU - Southey, Melissa C
AU - Goldgar, David E
AU - Buys, Saundra S
AU - Janavicius, Ramunas
AU - Dorfling, Cecilia M
AU - van Rensburg, Elizabeth J
AU - Ding, Yuan Chun
AU - Neuhausen, Susan L
AU - Hansen, Thomas v. O.
AU - Gerdes, Anne-Marie
AU - Ejlertsen, Bent
AU - Jønson, Lars
AU - Osorio, Ana
AU - Martínez-Bouzas, Cristina
AU - Benitez, Javier
AU - EMBRACE
N1 - ©2014 American Association for Cancer Research.
PY - 2015/1
Y1 - 2015/1
N2 - BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.METHODS: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.RESULTS: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.CONCLUSION: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.IMPACT: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies.
AB - BACKGROUND: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.METHODS: Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.RESULTS: The observed P values of association ranged between 0.005 and 1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either BRCA1 or BRCA2 mutation carriers, after multiple testing adjustments.CONCLUSION: There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.IMPACT: Genome-wide association studies have been more successful at identifying genetic modifiers of BRCA1/2 penetrance than candidate gene studies.
KW - Adult
KW - Breast Neoplasms
KW - Cohort Studies
KW - Female
KW - Genes, BRCA1
KW - Genes, BRCA2
KW - Humans
KW - Mutation
KW - Ovarian Neoplasms
KW - Polymorphism, Single Nucleotide
KW - Retrospective Studies
KW - Young Adult
U2 - 10.1158/1055-9965.EPI-14-0532
DO - 10.1158/1055-9965.EPI-14-0532
M3 - Journal article
C2 - 25336561
VL - 24
SP - 308
EP - 316
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
SN - 1055-9965
IS - 1
ER -