Cancer-associated lysosomal changes: friends or foes?

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Standard

Cancer-associated lysosomal changes : friends or foes? / Kallunki, T; Olsen, O D; Jaattela, Marja.

I: Oncogene, Bind 32, Nr. 16, 18.04.2013, s. 1995-2004.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kallunki, T, Olsen, OD & Jaattela, M 2013, 'Cancer-associated lysosomal changes: friends or foes?', Oncogene, bind 32, nr. 16, s. 1995-2004. https://doi.org/10.1038/onc.2012.292

APA

Kallunki, T., Olsen, O. D., & Jaattela, M. (2013). Cancer-associated lysosomal changes: friends or foes? Oncogene, 32(16), 1995-2004. https://doi.org/10.1038/onc.2012.292

Vancouver

Kallunki T, Olsen OD, Jaattela M. Cancer-associated lysosomal changes: friends or foes? Oncogene. 2013 apr. 18;32(16):1995-2004. https://doi.org/10.1038/onc.2012.292

Author

Kallunki, T ; Olsen, O D ; Jaattela, Marja. / Cancer-associated lysosomal changes : friends or foes?. I: Oncogene. 2013 ; Bind 32, Nr. 16. s. 1995-2004.

Bibtex

@article{c58bac68eb5349f2a9a4514cb221bc48,
title = "Cancer-associated lysosomal changes: friends or foes?",
abstract = "Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.Oncogene advance online publication, 9 July 2012; doi:10.1038/onc.2012.292.",
author = "T Kallunki and Olsen, {O D} and Marja Jaattela",
year = "2013",
month = apr,
day = "18",
doi = "10.1038/onc.2012.292",
language = "English",
volume = "32",
pages = "1995--2004",
journal = "Oncogene",
issn = "0950-9232",
publisher = "nature publishing group",
number = "16",

}

RIS

TY - JOUR

T1 - Cancer-associated lysosomal changes

T2 - friends or foes?

AU - Kallunki, T

AU - Olsen, O D

AU - Jaattela, Marja

PY - 2013/4/18

Y1 - 2013/4/18

N2 - Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.Oncogene advance online publication, 9 July 2012; doi:10.1038/onc.2012.292.

AB - Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.Oncogene advance online publication, 9 July 2012; doi:10.1038/onc.2012.292.

U2 - 10.1038/onc.2012.292

DO - 10.1038/onc.2012.292

M3 - Journal article

C2 - 22777359

VL - 32

SP - 1995

EP - 2004

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 16

ER -

ID: 38488402