Cancer predictive value of cytogenetic markers used in occupational health surveillance programs
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Cancer predictive value of cytogenetic markers used in occupational health surveillance programs. / Hagmar, L; Bonassi, S; Strömberg, U; Mikoczy, Z; Lando, C; Hansteen, I L; Montagud, A H; Knudsen, Lisbeth E.; Norppa, H; Reuterwall, C; Tinnerberg, H; Brøgger, A; Forni, A; Högstedt, B; Lambert, B; Mitelman, F; Nordenson, I; Salomaa, S; Skerfving, S.
I: Recent Results in Cancer Research, Bind 154, 1998, s. 177-84.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cancer predictive value of cytogenetic markers used in occupational health surveillance programs
AU - Hagmar, L
AU - Bonassi, S
AU - Strömberg, U
AU - Mikoczy, Z
AU - Lando, C
AU - Hansteen, I L
AU - Montagud, A H
AU - Knudsen, Lisbeth E.
AU - Norppa, H
AU - Reuterwall, C
AU - Tinnerberg, H
AU - Brøgger, A
AU - Forni, A
AU - Högstedt, B
AU - Lambert, B
AU - Mitelman, F
AU - Nordenson, I
AU - Salomaa, S
AU - Skerfving, S
N1 - Keywords: Biological Markers; Chromosome Aberrations; Health Surveys; Humans; Incidence; Micronuclei, Chromosome-Defective; Neoplasms; Occupational Health; Sister Chromatid Exchange
PY - 1998
Y1 - 1998
N2 - It has not previously been clear whether cytogenetic biomarkers in healthy subjects will predict cancer. Earlier analyses of a Nordic and an Italian cohort indicated predictivity for chromosomal aberrations (CAS) but not for sister chromatid exchanges (SCES). A pooled analysis of the updated cohorts, forming a joint study base of 5271 subjects, will now be performed, allowing a more solid evaluation. The importance of potential effect modifiers, such as gender, age at testing, and time since testing, will be evaluated using Poisson regression models. Two other potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.
AB - It has not previously been clear whether cytogenetic biomarkers in healthy subjects will predict cancer. Earlier analyses of a Nordic and an Italian cohort indicated predictivity for chromosomal aberrations (CAS) but not for sister chromatid exchanges (SCES). A pooled analysis of the updated cohorts, forming a joint study base of 5271 subjects, will now be performed, allowing a more solid evaluation. The importance of potential effect modifiers, such as gender, age at testing, and time since testing, will be evaluated using Poisson regression models. Two other potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.
M3 - Journal article
C2 - 10026999
VL - 154
SP - 177
EP - 184
JO - Recent Results in Cancer Research
JF - Recent Results in Cancer Research
SN - 0080-0015
ER -
ID: 17557490