Burden of sudden cardiac death in persons aged 1 to 49 years: nationwide study in Denmark
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Burden of sudden cardiac death in persons aged 1 to 49 years : nationwide study in Denmark. / Risgaard, Bjarke; Winkel, Bo Gregers; Jabbari, Reza; Behr, Elijah R; Ingemann-Hansen, Ole; Thomsen, Jørgen Lange; Ottesen, Gyda Lolk; Gislason, Gunnar H; Bundgaard, Henning; Haunsø, Stig; Holst, Anders Gaarsdal; Tfelt-Hansen, Jacob.
I: Circulation. Arrhythmia and electrophysiology, Bind 7, Nr. 2, 04.2014, s. 205-211.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Burden of sudden cardiac death in persons aged 1 to 49 years
T2 - nationwide study in Denmark
AU - Risgaard, Bjarke
AU - Winkel, Bo Gregers
AU - Jabbari, Reza
AU - Behr, Elijah R
AU - Ingemann-Hansen, Ole
AU - Thomsen, Jørgen Lange
AU - Ottesen, Gyda Lolk
AU - Gislason, Gunnar H
AU - Bundgaard, Henning
AU - Haunsø, Stig
AU - Holst, Anders Gaarsdal
AU - Tfelt-Hansen, Jacob
PY - 2014/4
Y1 - 2014/4
N2 - BACKGROUND: Knowledge of the burden and causes of sudden cardiac death (SCD) is sparse in persons aged<50 years; better understanding is needed to lower the risk of SCD. The aim of this study was to report SCD incidence rates and autopsy findings in persons aged 1 to 49 years.METHODS AND RESULTS: All deaths in persons aged 1 to 49 years were included in 2007 to 2009. Death certificates were reviewed by 2 physicians. History of previous admissions to hospital was assessed, and discharge summaries were read. Sudden unexpected death cases were identified and autopsy reports were collected. In the 3-year study period, there were 7849 deaths of which we identified 893 (11%) SCD cases. The annual incidence rate per 100 000 persons increased from 2.3 (95% confidence interval, 2.0-2.7) to 21.7 (95% confidence interval, 20.2-23.4) in persons aged 1 to 35 and 36 to 49 years, respectively. Coronary artery disease was the most common cause of death and was found in 158 (36%) autopsied cases, followed by 135 (31%) cases of sudden unexplained death.CONCLUSIONS: In a nationwide cohort of persons aged<50 years, the annual incidence rate of SCD was ≈10× higher in persons aged 36 to 49 years than in persons aged 1 to 35 years. Notably, coronary artery disease was the most common cause of SCD, followed by unexplained deaths. These findings may help in developing strategies to prevent SCD in the future.
AB - BACKGROUND: Knowledge of the burden and causes of sudden cardiac death (SCD) is sparse in persons aged<50 years; better understanding is needed to lower the risk of SCD. The aim of this study was to report SCD incidence rates and autopsy findings in persons aged 1 to 49 years.METHODS AND RESULTS: All deaths in persons aged 1 to 49 years were included in 2007 to 2009. Death certificates were reviewed by 2 physicians. History of previous admissions to hospital was assessed, and discharge summaries were read. Sudden unexpected death cases were identified and autopsy reports were collected. In the 3-year study period, there were 7849 deaths of which we identified 893 (11%) SCD cases. The annual incidence rate per 100 000 persons increased from 2.3 (95% confidence interval, 2.0-2.7) to 21.7 (95% confidence interval, 20.2-23.4) in persons aged 1 to 35 and 36 to 49 years, respectively. Coronary artery disease was the most common cause of death and was found in 158 (36%) autopsied cases, followed by 135 (31%) cases of sudden unexplained death.CONCLUSIONS: In a nationwide cohort of persons aged<50 years, the annual incidence rate of SCD was ≈10× higher in persons aged 36 to 49 years than in persons aged 1 to 35 years. Notably, coronary artery disease was the most common cause of SCD, followed by unexplained deaths. These findings may help in developing strategies to prevent SCD in the future.
KW - Adolescent
KW - Adult
KW - Age Distribution
KW - Autopsy
KW - Cause of Death
KW - Child
KW - Child, Preschool
KW - Coronary Artery Disease
KW - Death Certificates
KW - Death, Sudden, Cardiac
KW - Denmark
KW - Female
KW - Humans
KW - Incidence
KW - Infant
KW - Male
KW - Middle Aged
KW - Registries
KW - Retrospective Studies
KW - Sex Distribution
KW - Survival Rate
KW - Young Adult
U2 - 10.1161/CIRCEP.113.001421
DO - 10.1161/CIRCEP.113.001421
M3 - Journal article
C2 - 24604905
VL - 7
SP - 205
EP - 211
JO - Circulation: Arrhythmia and Electrophysiology
JF - Circulation: Arrhythmia and Electrophysiology
SN - 1941-3149
IS - 2
ER -
ID: 137511233