Brain-derived neurotrophic factor levels in newly diagnosed patients with bipolar disorder, their unaffected first-degree relatives and healthy controls
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Brain-derived neurotrophic factor levels in newly diagnosed patients with bipolar disorder, their unaffected first-degree relatives and healthy controls. / Petersen, Nanna Aagaard; Nielsen, Marc Ostergaard; Coello, Klara; Stanislaus, Sharleny; Melbye, Sigurd; Kjærstad, Hanne Lie; Sletved, Kimie Stefanie Ormstrup; McIntyre, Roger S.; Frikke-Smith, Ruth; Vinberg, Maj; Kessing, Lars Vedel.
I: BJPsych Open, Bind 7, Nr. 2, e55, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Brain-derived neurotrophic factor levels in newly diagnosed patients with bipolar disorder, their unaffected first-degree relatives and healthy controls
AU - Petersen, Nanna Aagaard
AU - Nielsen, Marc Ostergaard
AU - Coello, Klara
AU - Stanislaus, Sharleny
AU - Melbye, Sigurd
AU - Kjærstad, Hanne Lie
AU - Sletved, Kimie Stefanie Ormstrup
AU - McIntyre, Roger S.
AU - Frikke-Smith, Ruth
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
N1 - Publisher Copyright: Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists.
PY - 2021
Y1 - 2021
N2 - Background Brain-derived neurotrophic factor (BDNF), which facilitates neuroplasticity and synaptogenesis, may be decreased in bipolar disorder, but has not been systematically investigated in people with newly diagnosed bipolar disorder and unaffected first-degree relatives. Aims To compare BDNF levels in patients with newly diagnosed bipolar disorder, their unaffected first-degree relatives and healthy controls. Method The study investigated plasma BDNF levels in patients (n = 371) with newly diagnosed bipolar disorder, their unaffected first-degree relatives (n = 98) and healthy controls (n = 200) using enzyme-linked immunosorbent assay. We further investigated associations between BDNF levels and illness-related variables and medication status. Results BDNF levels were found to be 22.0% (95% CI 1.107-1.343) higher in patients with bipolar disorder compared with healthy controls (P < 0.001) and 15.6% higher in unaffected first-degree relatives compared with healthy controls (95% CI 1.007-1.327, P = 0.04), when adjusting for age and gender. Further, BDNF levels were positively associated with duration of illness at a trend level (P = 0.05), age (P = 0.001) and use of anti-epileptic medication (P = 0.05). Conclusions These findings suggest that BDNF levels are not decreased in the early stages of bipolar disorder and in unaffected first-degree relatives contrasting with prior findings during later stages of the illness.
AB - Background Brain-derived neurotrophic factor (BDNF), which facilitates neuroplasticity and synaptogenesis, may be decreased in bipolar disorder, but has not been systematically investigated in people with newly diagnosed bipolar disorder and unaffected first-degree relatives. Aims To compare BDNF levels in patients with newly diagnosed bipolar disorder, their unaffected first-degree relatives and healthy controls. Method The study investigated plasma BDNF levels in patients (n = 371) with newly diagnosed bipolar disorder, their unaffected first-degree relatives (n = 98) and healthy controls (n = 200) using enzyme-linked immunosorbent assay. We further investigated associations between BDNF levels and illness-related variables and medication status. Results BDNF levels were found to be 22.0% (95% CI 1.107-1.343) higher in patients with bipolar disorder compared with healthy controls (P < 0.001) and 15.6% higher in unaffected first-degree relatives compared with healthy controls (95% CI 1.007-1.327, P = 0.04), when adjusting for age and gender. Further, BDNF levels were positively associated with duration of illness at a trend level (P = 0.05), age (P = 0.001) and use of anti-epileptic medication (P = 0.05). Conclusions These findings suggest that BDNF levels are not decreased in the early stages of bipolar disorder and in unaffected first-degree relatives contrasting with prior findings during later stages of the illness.
KW - Bipolar disorder
KW - brain-derived neurotrophic factor
KW - recent onset
KW - unaffected relatives
U2 - 10.1192/bjo.2021.9
DO - 10.1192/bjo.2021.9
M3 - Journal article
C2 - 33588978
AN - SCOPUS:85105816672
VL - 7
JO - BJPsych Open
JF - BJPsych Open
SN - 2056-4724
IS - 2
M1 - e55
ER -
ID: 273653382