Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The pathogenesis of cerebral edema in acute liver failure is suggested, in in vitro and animal studies, to involve a compromised oxidative metabolism with a decrease in cerebral ATP levels and an increase in purine concentrations. In this study we hypothesize that the cerebral concentrations of hypoxanthine, inosine, and lactate/pyruvate (LP) ratio are increased and correlated in patients with acute liver failure. Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively).
Originalsprog | Engelsk |
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Tidsskrift | Journal of Hepatology |
Vol/bind | 53 |
Udgave nummer | 6 |
Sider (fra-til) | 1054-8 |
Antal sider | 5 |
ISSN | 0168-8278 |
DOI | |
Status | Udgivet - 1 dec. 2010 |
ID: 34074302