Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Bone From Blood : Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells. / Feehan, Jack; Kassem, Moustapha; Pignolo, Robert J.; Duque, Gustavo.
I: Journal of Bone and Mineral Research, Bind 36, Nr. 1, 2021, s. 12-23.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Bone From Blood
T2 - Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells
AU - Feehan, Jack
AU - Kassem, Moustapha
AU - Pignolo, Robert J.
AU - Duque, Gustavo
PY - 2021
Y1 - 2021
N2 - Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.
AB - Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.
KW - CIRCULATING OSTEOGENIC PRECURSOR CELLS
KW - COP CELLS
KW - FRACTURE
KW - FRAILTY
KW - HETEROTOPIC OSSIFICATION
KW - OSTEOPOROSIS
KW - VASCULAR CALCIFICATION
U2 - 10.1002/jbmr.4204
DO - 10.1002/jbmr.4204
M3 - Review
C2 - 33118647
AN - SCOPUS:85096761725
VL - 36
SP - 12
EP - 23
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 1
ER -
ID: 252677175