Body Mass Index Changes and Insulin Resistance at Age 4: A Prospective Cohort Study
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Body Mass Index Changes and Insulin Resistance at Age 4 : A Prospective Cohort Study. / Lee, Hye Jin; Lim, Youn-Hee; Hong, Yun-Chul; Shin, Choong Ho; Lee, Young Ah.
I: Frontiers in Endocrinology, Bind 13, 872591, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Body Mass Index Changes and Insulin Resistance at Age 4
T2 - A Prospective Cohort Study
AU - Lee, Hye Jin
AU - Lim, Youn-Hee
AU - Hong, Yun-Chul
AU - Shin, Choong Ho
AU - Lee, Young Ah
N1 - Copyright © 2022 Lee, Lim, Hong, Shin and Lee.
PY - 2022
Y1 - 2022
N2 - Objectives: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood.Methods: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (μIU/ml) × glucose (mg/dl)/405. The BMI Z-score [BMI (Z)] quartiles for each age group were defined as Q4, ≥75th percentile; Q2-3, 25th to 75th percentile; and Q1, <25th percentile. Glucose, insulin, and the HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4.Results: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dl), insulin (3.2 vs. 2.5 and 2.3 μIU/ml), and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2-3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2-3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2-3 at age 4 did not affect glucose or IR at 4 years.Conclusion: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group.
AB - Objectives: The objective of this study is to investigate whether body mass index (BMI) changes are associated with fasting glucose and insulin resistance (IR) in early childhood.Methods: From the Environment and Development of Children (EDC) cohort, 334 children who visited at ages 2 and 4 were included in this study. Height and weight were measured at ages 2 and 4, and fasting glucose and insulin were assessed at age 4. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (μIU/ml) × glucose (mg/dl)/405. The BMI Z-score [BMI (Z)] quartiles for each age group were defined as Q4, ≥75th percentile; Q2-3, 25th to 75th percentile; and Q1, <25th percentile. Glucose, insulin, and the HOMA-IR were compared between groups according to the change in BMI (Z) from age 2 to 4.Results: Children who stayed in Q4 at both ages had higher fasting glucose (92.2 vs. 88.0 and 87.1 mg/dl), insulin (3.2 vs. 2.5 and 2.3 μIU/ml), and HOMA-IR (0.68 vs. 0.54 and 0.52) than children who stayed in Q1 or Q2-3 (all P<0.01). Children in Q4 at both ages had higher fasting glucose than children whose BMI (Z) increased from Q1 or Q2-3 to Q4 (92.2 vs. 87.3, P<0.001). The BMI (Z) category at age 2 of children who were in Q2-3 at age 4 did not affect glucose or IR at 4 years.Conclusion: The group of children within the highest BMI (Z) quartile at both 2 and 4 years of age had higher fasting glucose and IR at age 4 than any other BMI (Z) change group.
KW - Body Mass Index
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Glucose
KW - Humans
KW - Insulin
KW - Insulin Resistance
KW - Prospective Studies
U2 - 10.3389/fendo.2022.872591
DO - 10.3389/fendo.2022.872591
M3 - Journal article
C2 - 35677718
VL - 13
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
M1 - 872591
ER -
ID: 310070650