Blood-brain barrier permeability of L-dopa in man
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Clinical Investigation |
Vol/bind | 11 |
Udgave nummer | 3 |
Sider (fra-til) | 231-4 |
Antal sider | 4 |
ISSN | 0014-2972 |
DOI | |
Status | Udgivet - jun. 1981 |
ID: 279595766