BK channel activators and their therapeutic perspectives
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BK channel activators and their therapeutic perspectives. / Bentzen, Bo Hjorth; Olesen, Søren-Peter; Rønn, Lars C B; Grunnet, Morten.
I: Frontiers in Physiology, Bind 5, 2014, s. 1-12.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - BK channel activators and their therapeutic perspectives
AU - Bentzen, Bo Hjorth
AU - Olesen, Søren-Peter
AU - Rønn, Lars C B
AU - Grunnet, Morten
PY - 2014
Y1 - 2014
N2 - The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.
AB - The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important negative feedback system linking increases in intracellular calcium to outward hyperpolarizing potassium currents. Consequently, the channel has many important physiological roles including regulation of smooth muscle tone, neurotransmitter release and neuronal excitability. Additionally, cardioprotective roles have been revealed in recent years. After a short introduction to the structure, function and regulation of BK channels, we review the small organic molecules activating BK channels and how these tool compounds have helped delineate the roles of BK channels in health and disease.
U2 - 10.3389/fphys.2014.00389
DO - 10.3389/fphys.2014.00389
M3 - Journal article
C2 - 25346695
VL - 5
SP - 1
EP - 12
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
ER -
ID: 135363229