Birth weight and subclinical cardiovascular and renal damage in a population-based study (the STANISLAS cohort study)
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Birth weight and subclinical cardiovascular and renal damage in a population-based study (the STANISLAS cohort study). / Lopez-Sublet, Marilucy; Merkling, Thomas; Girerd, Nicolas; Xhaard, Constance; Flahault, Adrien; Bozec, Erwan; Leroy, Celine; Fujikawa, Tomona; Vaag, Allan Arthur; Mebazaa, Alexandre; Kistorp, Caroline Michaela; Heude, Barbara; Boivin, Jean Marc; Zannad, Faiez; Wagner, Sandra; Rossignol, Patrick.
I: Journal of Hypertension, Bind 41, Nr. 6, 2023, s. 1040-1050.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Birth weight and subclinical cardiovascular and renal damage in a population-based study (the STANISLAS cohort study)
AU - Lopez-Sublet, Marilucy
AU - Merkling, Thomas
AU - Girerd, Nicolas
AU - Xhaard, Constance
AU - Flahault, Adrien
AU - Bozec, Erwan
AU - Leroy, Celine
AU - Fujikawa, Tomona
AU - Vaag, Allan Arthur
AU - Mebazaa, Alexandre
AU - Kistorp, Caroline Michaela
AU - Heude, Barbara
AU - Boivin, Jean Marc
AU - Zannad, Faiez
AU - Wagner, Sandra
AU - Rossignol, Patrick
N1 - Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Objective:Although preterm-born and low-birth-weight individuals have an increased risk of cardiovascular diseases in adulthood, little is known regarding early cardiovascular and renal damage (CVRD) or hypertension in adulthood. Our study investigated the association of birth weight with early CVRD markers as well as the heritability of birth weight in an initially healthy family-based cohort.Methods:This study was based on 1028 individuals from the familial longitudinal STANISLAS cohort (399 parents/629 children) initiated in 1993-1995, with a fourth examination conducted in 2011-2016. Analyses performed at the fourth visit included pulse-wave velocity, central pressure, ambulatory blood pressure, hypertension status, diastolic dysfunction/distensibility, left ventricular mass indexed (LVMI), carotid intima-media thickness and kidney damage. The family structure of the cohort allowed birth weight heritability estimation.Results:Mean (±SD) birth weight was 3.3 ± 0.6 kg. Heritability was moderate (42-44%). At the fourth visit, individuals were 37 years old (32.0-57.0), 56% were women and 13% had antihypertensive treatment. Birth weight was strongly and negatively associated with hypertension [odds ratio (OR) 95% confidence interval (CI) 0.61 (0.45-0.84)]. A nonlinear association was found with LVMI, participants with a birth weight greater than 3 kg having a higher LVMI. A positive association (β 95% CI 5.09 (1.8-8.38)] was also observed between birth weight and distensibility for adults with normal BMI. No associations were found with other CVRD.Conclusion:In this middle-Aged population, birth weight was strongly and negatively associated with hypertension, and positively associated with distensibility in adults with normal BMI and with LVMI for higher birth weights. No associations were found with other CVRD markers.
AB - Objective:Although preterm-born and low-birth-weight individuals have an increased risk of cardiovascular diseases in adulthood, little is known regarding early cardiovascular and renal damage (CVRD) or hypertension in adulthood. Our study investigated the association of birth weight with early CVRD markers as well as the heritability of birth weight in an initially healthy family-based cohort.Methods:This study was based on 1028 individuals from the familial longitudinal STANISLAS cohort (399 parents/629 children) initiated in 1993-1995, with a fourth examination conducted in 2011-2016. Analyses performed at the fourth visit included pulse-wave velocity, central pressure, ambulatory blood pressure, hypertension status, diastolic dysfunction/distensibility, left ventricular mass indexed (LVMI), carotid intima-media thickness and kidney damage. The family structure of the cohort allowed birth weight heritability estimation.Results:Mean (±SD) birth weight was 3.3 ± 0.6 kg. Heritability was moderate (42-44%). At the fourth visit, individuals were 37 years old (32.0-57.0), 56% were women and 13% had antihypertensive treatment. Birth weight was strongly and negatively associated with hypertension [odds ratio (OR) 95% confidence interval (CI) 0.61 (0.45-0.84)]. A nonlinear association was found with LVMI, participants with a birth weight greater than 3 kg having a higher LVMI. A positive association (β 95% CI 5.09 (1.8-8.38)] was also observed between birth weight and distensibility for adults with normal BMI. No associations were found with other CVRD.Conclusion:In this middle-Aged population, birth weight was strongly and negatively associated with hypertension, and positively associated with distensibility in adults with normal BMI and with LVMI for higher birth weights. No associations were found with other CVRD markers.
KW - arterial stiffness
KW - birth weight
KW - cardiovascular and renal damage
KW - echocardiographic diastolic dysfunction
KW - heritability
KW - intima-media thickness
KW - microalbuminuria
KW - renal disease
U2 - 10.1097/HJH.0000000000003438
DO - 10.1097/HJH.0000000000003438
M3 - Journal article
C2 - 37071444
AN - SCOPUS:85158868734
VL - 41
SP - 1040
EP - 1050
JO - Journal of Hypertension, Supplement
JF - Journal of Hypertension, Supplement
SN - 0952-1178
IS - 6
ER -
ID: 393769581