Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders
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Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders. / Jensen, Jacob K.; Nygaard, Rie H.; Svensson, Rene B.; Hove, Hanne D.; Magnusson, S. Peter; Kjær, Michael; Couppé, Christian.
I: European Journal of Applied Physiology, Bind 118, Nr. 7, 2018, s. 1301-1307.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders
AU - Jensen, Jacob K.
AU - Nygaard, Rie H.
AU - Svensson, Rene B.
AU - Hove, Hanne D.
AU - Magnusson, S. Peter
AU - Kjær, Michael
AU - Couppé, Christian
PY - 2018
Y1 - 2018
N2 - Purpose: Hereditary connective tissue disorders (HCTDs), such as classic Ehlers–Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from healthy children. The purpose of this study was to investigate the biomechanical properties of the patellar tendon and joint laxity (Beighton score) in children with HCTDs (n = 7) compared to healthy controls (n = 14). Methods: The mechanical properties of the patellar tendon were assessed using simultaneous force and ultrasonographic measurements during isometric ramp contractions. Ultrasonography was also used to measure tendon dimensions. The HCTD children were matched with 2 healthy controls with regard to age, body mass index (BMI), sex and physical activity level. Results: The HCTD children had a greater degree of joint laxity (P < 0.01). Although, the patellar tendon dimensions did not differ significantly between the two groups, the HCTD children showed a tendency toward a larger patellar tendon cross-sectional area (CSA) (35%, P = 0.19). Moreover, stiffness did not differ between the two groups, but secant modulus was 27% lower in children with a HCTD (P = 0.05) at common force and 34% lower at maximum force (P = 0.02). Conclusions: The present study demonstrates for the first time that children with HCTDs have lower material properties (modulus) of their patellar tendon, which may be indicative of general impairment of connective tissue mechanics related to their increased joint laxity.
AB - Purpose: Hereditary connective tissue disorders (HCTDs), such as classic Ehlers–Danlos syndrome (cEDS) and Marfan syndrome (MS) share overlapping features like hypermobility and tissue fragility. In clinical practice it remains a challenge to distinguish children and adolescents with HCTD from healthy children. The purpose of this study was to investigate the biomechanical properties of the patellar tendon and joint laxity (Beighton score) in children with HCTDs (n = 7) compared to healthy controls (n = 14). Methods: The mechanical properties of the patellar tendon were assessed using simultaneous force and ultrasonographic measurements during isometric ramp contractions. Ultrasonography was also used to measure tendon dimensions. The HCTD children were matched with 2 healthy controls with regard to age, body mass index (BMI), sex and physical activity level. Results: The HCTD children had a greater degree of joint laxity (P < 0.01). Although, the patellar tendon dimensions did not differ significantly between the two groups, the HCTD children showed a tendency toward a larger patellar tendon cross-sectional area (CSA) (35%, P = 0.19). Moreover, stiffness did not differ between the two groups, but secant modulus was 27% lower in children with a HCTD (P = 0.05) at common force and 34% lower at maximum force (P = 0.02). Conclusions: The present study demonstrates for the first time that children with HCTDs have lower material properties (modulus) of their patellar tendon, which may be indicative of general impairment of connective tissue mechanics related to their increased joint laxity.
KW - Hereditary connective tissue disorders
KW - Joint hypermobility
KW - Patellar tendon mechanics
KW - Tendon biomechanics
U2 - 10.1007/s00421-018-3862-7
DO - 10.1007/s00421-018-3862-7
M3 - Journal article
C2 - 29623400
AN - SCOPUS:85045070743
VL - 118
SP - 1301
EP - 1307
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
SN - 1439-6319
IS - 7
ER -
ID: 218436138