Bilateral diffuse uveal melanocytic proliferation: Case report and literature review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Bilateral diffuse uveal melanocytic proliferation : Case report and literature review. / Klemp, Kristian; Kiilgaard, Jens Folke; Heegaard, Steffen; Nørgaard, Tove; Andersen, Mette Klarskov; Prause, Jan Ulrik.
I: Acta Ophthalmologica, Bind 95, Nr. 5, 2017, s. 439-445.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Bilateral diffuse uveal melanocytic proliferation
T2 - Case report and literature review
AU - Klemp, Kristian
AU - Kiilgaard, Jens Folke
AU - Heegaard, Steffen
AU - Nørgaard, Tove
AU - Andersen, Mette Klarskov
AU - Prause, Jan Ulrik
PY - 2017
Y1 - 2017
N2 - Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.
AB - Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.
KW - bilateral
KW - diffuse
KW - melanocytic
KW - proliferation
KW - uveal
U2 - 10.1111/aos.13481
DO - 10.1111/aos.13481
M3 - Review
C2 - 28636126
AN - SCOPUS:85021096402
VL - 95
SP - 439
EP - 445
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 5
ER -
ID: 182123903