beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.
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beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia. / Marsal, Jan; Brakebusch, Cord; Bungartz, Gerd; Fässler, Reinhard; Agace, William W.
I: European Journal of Immunology, Bind 35, Nr. 6, 2005, s. 1805-11.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.
AU - Marsal, Jan
AU - Brakebusch, Cord
AU - Bungartz, Gerd
AU - Fässler, Reinhard
AU - Agace, William W
N1 - Keywords: Animals; Antigens, CD29; Integrin alpha1beta1; Intestinal Mucosa; Lymphocytes; Mice; Mice, Inbred C57BL
PY - 2005
Y1 - 2005
N2 - beta(1) integrins are thought to play a central role in maintaining lymphocytes within mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial cellular components within and underlying the basement membrane. In the current study type a (CD8alphabetaTCRalphabeta) and type b (CD8alphaalphaTCRgammadelta and CD8alphaalphaTCRalphabeta) intraepithelial lymphocyte (IEL) subsets within the mouse small intestine were found to express functional beta(1) integrin and the beta(1) integrin alpha chain partners alpha(1), alpha(2), and alpha(4). Using inducible beta(1) integrin-knockout bone marrow-chimeric mice we demonstrate that IEL expression of alpha(1) and alpha(2) but not alpha(4) is dependent on expression of the beta(1) chain. Importantly, deletion of the beta(1) chain in IEL did not alter the number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL express functional beta(1) integrins, these are not required to maintain lymphocytes within intestinal epithelia. This result is discussed in the light of conventional views of intestinal lymphocyte homing and localization.
AB - beta(1) integrins are thought to play a central role in maintaining lymphocytes within mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial cellular components within and underlying the basement membrane. In the current study type a (CD8alphabetaTCRalphabeta) and type b (CD8alphaalphaTCRgammadelta and CD8alphaalphaTCRalphabeta) intraepithelial lymphocyte (IEL) subsets within the mouse small intestine were found to express functional beta(1) integrin and the beta(1) integrin alpha chain partners alpha(1), alpha(2), and alpha(4). Using inducible beta(1) integrin-knockout bone marrow-chimeric mice we demonstrate that IEL expression of alpha(1) and alpha(2) but not alpha(4) is dependent on expression of the beta(1) chain. Importantly, deletion of the beta(1) chain in IEL did not alter the number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL express functional beta(1) integrins, these are not required to maintain lymphocytes within intestinal epithelia. This result is discussed in the light of conventional views of intestinal lymphocyte homing and localization.
U2 - 10.1002/eji.200425941
DO - 10.1002/eji.200425941
M3 - Journal article
C2 - 15884052
VL - 35
SP - 1805
EP - 1811
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 6
ER -
ID: 5141188