Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study
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Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study. / Sen, Abhijit; Tsilidis, Konstantinos K.; Allen, Naomi E.; Rinaldi, Sabina; Appleby, Paul N.; Almquist, Martin; Schmidt, Julie A.; Dahm, Christina C.; Overvad, Kim; Tjønneland, Anne; Rostgaard-Hansen, Agnetha Linn; Clavel-Chapelon, Françoise; Baglietto, Laura; Boutron-Ruault, Marie Christine; Kühn, Tilman; Katze, Verena A.; Boeing, Heiner; Trichopoulou, Antonia; Tsironis, Christos; Lagiou, Pagona; Palli, Domenico; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquita, H. B.; Peeters, Petra H.; Hjartåker, Anette; Lund, Eiliv; Weiderpass, Elisabete; Quirós, J. Ramón; Agudo, Antonio; Sánchez, María José; Arriola, Larraitz; Gavrila, Diana; Gurrea, Aurelio Barricarte; Tosovic, Ada; Hennings, Joakim; Sandström, Maria; Romieu, Isabelle; Ferrari, Pietro; Zamora-Ros, Raul; Khaw, Kay Tee; Wareham, Nicholas J.; Riboli, Elio; Gunter, Marc; Franceschi, Silvia.
I: B J C, Bind 113, Nr. 5, 2015, s. 840-847.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study
AU - Sen, Abhijit
AU - Tsilidis, Konstantinos K.
AU - Allen, Naomi E.
AU - Rinaldi, Sabina
AU - Appleby, Paul N.
AU - Almquist, Martin
AU - Schmidt, Julie A.
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Rostgaard-Hansen, Agnetha Linn
AU - Clavel-Chapelon, Françoise
AU - Baglietto, Laura
AU - Boutron-Ruault, Marie Christine
AU - Kühn, Tilman
AU - Katze, Verena A.
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Tsironis, Christos
AU - Lagiou, Pagona
AU - Palli, Domenico
AU - Pala, Valeria
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Bueno-de-Mesquita, H. B.
AU - Peeters, Petra H.
AU - Hjartåker, Anette
AU - Lund, Eiliv
AU - Weiderpass, Elisabete
AU - Quirós, J. Ramón
AU - Agudo, Antonio
AU - Sánchez, María José
AU - Arriola, Larraitz
AU - Gavrila, Diana
AU - Gurrea, Aurelio Barricarte
AU - Tosovic, Ada
AU - Hennings, Joakim
AU - Sandström, Maria
AU - Romieu, Isabelle
AU - Ferrari, Pietro
AU - Zamora-Ros, Raul
AU - Khaw, Kay Tee
AU - Wareham, Nicholas J.
AU - Riboli, Elio
AU - Gunter, Marc
AU - Franceschi, Silvia
PY - 2015
Y1 - 2015
N2 - Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.
AB - Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.
KW - Alcohol consumption
KW - Lifetime exposure
KW - Prospective study
KW - Thyroid carcinoma
U2 - 10.1038/bjc.2015.280
DO - 10.1038/bjc.2015.280
M3 - Journal article
C2 - 26313664
AN - SCOPUS:84940788094
VL - 113
SP - 840
EP - 847
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
IS - 5
ER -
ID: 218466000