Basal stamcellebiologi og cancer
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Basal stamcellebiologi og cancer. / Porse, Bo T; Petersen, Ole W; Helin, Kristian.
I: Ugeskrift for læger, Bind 172, Nr. 38, 20.09.2010, s. 2600-3.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Basal stamcellebiologi og cancer
AU - Porse, Bo T
AU - Petersen, Ole W
AU - Helin, Kristian
PY - 2010/9/20
Y1 - 2010/9/20
N2 - The finding that tumours, like normal tissues, are endowed with varying degrees of cellular heterogeneity has far-reaching consequences for our understanding of cancer. The cancer stem cell and clonal evolution models have both been proposed to explain tumour-associated cellular heterogeneity. Here, we briefly review these two non-exclusive models with special emphasis on how they aid our understanding of cancer and their implications for therapeutic strategies. Finally, we discuss the close association between basic stem cell biology and cancer, focusing on the role of self-renewal.
AB - The finding that tumours, like normal tissues, are endowed with varying degrees of cellular heterogeneity has far-reaching consequences for our understanding of cancer. The cancer stem cell and clonal evolution models have both been proposed to explain tumour-associated cellular heterogeneity. Here, we briefly review these two non-exclusive models with special emphasis on how they aid our understanding of cancer and their implications for therapeutic strategies. Finally, we discuss the close association between basic stem cell biology and cancer, focusing on the role of self-renewal.
KW - Antineoplastic Agents
KW - Drug Discovery
KW - Humans
KW - Models, Biological
KW - Neoplasms
KW - Neoplastic Stem Cells
M3 - Tidsskriftartikel
C2 - 20920403
VL - 172
SP - 2600
EP - 2603
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 38
ER -
ID: 33750462