Automatic, electrocardiographic-based detection of autonomic arousals and their association with cortical arousals, leg movements, and respiratory events in sleep
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Automatic, electrocardiographic-based detection of autonomic arousals and their association with cortical arousals, leg movements, and respiratory events in sleep. / Olsen, Mads; Schneider, Logan Douglas; Cheung, Joseph; Peppard, Paul E; Jennum, Poul J; Mignot, Emmanuel; Sorensen, Helge Bjarup Dissing.
I: Sleep, Bind 41, Nr. 3, zsy006, 2018.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Automatic, electrocardiographic-based detection of autonomic arousals and their association with cortical arousals, leg movements, and respiratory events in sleep
AU - Olsen, Mads
AU - Schneider, Logan Douglas
AU - Cheung, Joseph
AU - Peppard, Paul E
AU - Jennum, Poul J
AU - Mignot, Emmanuel
AU - Sorensen, Helge Bjarup Dissing
PY - 2018
Y1 - 2018
N2 - Study Objectives: The current definition of sleep arousals neglects to address the diversity of arousals and their systemic cohesion. Autonomic arousals (AA) are autonomic activations often associated with cortical arousals (CA), but they may also occur in relation to a respiratory event, a leg movement event or spontaneously, without any other physiological associations. AA should be acknowledged as essential events to understand and explore the systemic implications of arousals.Methods: We developed an automatic AA detection algorithm based on intelligent feature selection and advanced machine learning using the electrocardiogram. The model was trained and tested with respect to CA systematically scored in 258 (181 training size/77 test size) polysomnographic recordings from the Wisconsin Sleep Cohort.Results: A precision value of 0.72 and a sensitivity of 0.63 were achieved when evaluated with respect to CA. Further analysis indicated that 81% of the non-CA-associated AAs were associated with leg movement (38%) or respiratory (43%) events.Conclusions: The presented algorithm shows good performance when considering that more than 80% of the false positives (FP) found by the detection algorithm appeared in relation to either leg movement or respiratory events. This indicates that most FP constitute autonomic activations that are indistinguishable from those with cortical cohesion. The proposed algorithm provides an automatic system trained in a clinical environment, which can be utilized to analyze the systemic and clinical impacts of arousals.
AB - Study Objectives: The current definition of sleep arousals neglects to address the diversity of arousals and their systemic cohesion. Autonomic arousals (AA) are autonomic activations often associated with cortical arousals (CA), but they may also occur in relation to a respiratory event, a leg movement event or spontaneously, without any other physiological associations. AA should be acknowledged as essential events to understand and explore the systemic implications of arousals.Methods: We developed an automatic AA detection algorithm based on intelligent feature selection and advanced machine learning using the electrocardiogram. The model was trained and tested with respect to CA systematically scored in 258 (181 training size/77 test size) polysomnographic recordings from the Wisconsin Sleep Cohort.Results: A precision value of 0.72 and a sensitivity of 0.63 were achieved when evaluated with respect to CA. Further analysis indicated that 81% of the non-CA-associated AAs were associated with leg movement (38%) or respiratory (43%) events.Conclusions: The presented algorithm shows good performance when considering that more than 80% of the false positives (FP) found by the detection algorithm appeared in relation to either leg movement or respiratory events. This indicates that most FP constitute autonomic activations that are indistinguishable from those with cortical cohesion. The proposed algorithm provides an automatic system trained in a clinical environment, which can be utilized to analyze the systemic and clinical impacts of arousals.
KW - Adult
KW - Aged
KW - Algorithms
KW - Arousal/physiology
KW - Autonomic Nervous System/physiology
KW - Electrocardiography/methods
KW - Electroencephalography
KW - Female
KW - Humans
KW - Leg/physiology
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Movement/physiology
KW - Polysomnography/methods
KW - Respiratory Mechanics/physiology
KW - Sleep/physiology
KW - Sleep Apnea, Obstructive/diagnosis
KW - Wisconsin/epidemiology
U2 - 10.1093/sleep/zsy006
DO - 10.1093/sleep/zsy006
M3 - Journal article
C2 - 29329416
VL - 41
JO - Sleep (Online)
JF - Sleep (Online)
SN - 0161-8105
IS - 3
M1 - zsy006
ER -
ID: 218088620