Autoimmune and atopic disorders and risk of classical hodgkin lymphoma
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Autoimmune and atopic disorders and risk of classical hodgkin lymphoma. / Hollander, Peter; Rostgaard, Klaus; Smedby, Karin E.; Chang, Ellen T.; Amini, Rose Marie; De Nully Brown, Peter; Glimelius, Bengt; Adami, Hans Olov; Melbye, Mads; Glimelius, Ingrid; Hjalgrim, Henrik.
I: American Journal of Epidemiology, Bind 182, Nr. 7, 01.10.2015, s. 624-632.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Autoimmune and atopic disorders and risk of classical hodgkin lymphoma
AU - Hollander, Peter
AU - Rostgaard, Klaus
AU - Smedby, Karin E.
AU - Chang, Ellen T.
AU - Amini, Rose Marie
AU - De Nully Brown, Peter
AU - Glimelius, Bengt
AU - Adami, Hans Olov
AU - Melbye, Mads
AU - Glimelius, Ingrid
AU - Hjalgrim, Henrik
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Results from previous investigations have shown associations between the risk of Hodgkin lymphoma (HL) and a history of autoimmune and atopic diseases, but it remains unknown whether these associations apply to all types of HL or only to specific subtypes. We investigated immune diseases and the risk of classical HL in a population-based case-control study that included 585 patients and 3,187 controls recruited from October 1999 through August 2002. We collected information on immune diseases through telephone interviews and performed serological analyses of specific immunoglobulin E reactivity. Tumor Epstein-Barr virus (EBV) status was determined for 498 patients. Odds ratios with 95% confidence intervals were calculated using logistic regression analysis. Rheumatoid arthritis was associated with a higher risk of HL (odds ratio (OR) = 2.63; 95% confidence interval (CI): 1.47, 4.70), especially EBV-positive HL (OR = 3.18; 95% CI: 1.23, 8.17), and with mixed-cellularity HL (OR = 4.25; 95% CI: 1.66, 10.90). HL risk was higher when we used proxies of severe rheumatoid arthritis, such as ever having received daily rheumatoid arthritis medication (OR = 3.98; 95% CI: 2.08, 7.62), rheumatoid arthritis duration of 6-20 years (OR = 3.80; 95% CI: 1.72, 8.41), or ever having been hospitalized for rheumatoid arthritis (OR = 7.36; 95% CI: 2.95, 18.38). Atopic diseases were not associated with the risk of HL. EBV replication induced by chronic inflammation in patients with autoimmune diseases might explain the higher risk of EBV-positive HL.
AB - Results from previous investigations have shown associations between the risk of Hodgkin lymphoma (HL) and a history of autoimmune and atopic diseases, but it remains unknown whether these associations apply to all types of HL or only to specific subtypes. We investigated immune diseases and the risk of classical HL in a population-based case-control study that included 585 patients and 3,187 controls recruited from October 1999 through August 2002. We collected information on immune diseases through telephone interviews and performed serological analyses of specific immunoglobulin E reactivity. Tumor Epstein-Barr virus (EBV) status was determined for 498 patients. Odds ratios with 95% confidence intervals were calculated using logistic regression analysis. Rheumatoid arthritis was associated with a higher risk of HL (odds ratio (OR) = 2.63; 95% confidence interval (CI): 1.47, 4.70), especially EBV-positive HL (OR = 3.18; 95% CI: 1.23, 8.17), and with mixed-cellularity HL (OR = 4.25; 95% CI: 1.66, 10.90). HL risk was higher when we used proxies of severe rheumatoid arthritis, such as ever having received daily rheumatoid arthritis medication (OR = 3.98; 95% CI: 2.08, 7.62), rheumatoid arthritis duration of 6-20 years (OR = 3.80; 95% CI: 1.72, 8.41), or ever having been hospitalized for rheumatoid arthritis (OR = 7.36; 95% CI: 2.95, 18.38). Atopic diseases were not associated with the risk of HL. EBV replication induced by chronic inflammation in patients with autoimmune diseases might explain the higher risk of EBV-positive HL.
KW - atopic hypersensitivity
KW - Epstein-Barr virus
KW - Hodgkin lymphoma
KW - primary Sjögren's syndrome
KW - rheumatoid arthritis
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84943572441&partnerID=8YFLogxK
U2 - 10.1093/aje/kwv081
DO - 10.1093/aje/kwv081
M3 - Journal article
C2 - 26346543
AN - SCOPUS:84943572441
VL - 182
SP - 624
EP - 632
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 7
ER -
ID: 258831790