At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
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At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia. / Hansen, Thomas; Ingason, Andrés; Djurovic, Srdjan; Melle, Ingrid; Fenger, Mogens; Gustafsson, Omar; Jakobsen, Klaus D; Rasmussen, Henrik B; Tosato, Sarah; Rietschel, Marcella; Frank, Josef; Owen, Mike; Bonetto, Chiara; Suvisaari, Jaana; Thygesen, Johan Hilge; Pétursson, Hannes; Lönnqvist, Jouko; Sigurdsson, Engilbert; Giegling, Ina; Craddock, Nick; O'Donovan, Michael C; Ruggeri, Mirella; Cichon, Sven; Ophoff, Roel A; Pietiläinen, Olli; Peltonen, Leena; Nöthen, Markus M; Rujescu, Dan; St Clair, David; Collier, David A; Andreassen, Ole A; Werge, Thomas.
I: Biological Psychiatry, Bind 70, Nr. 1, 01.07.2011, s. 59-63.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
AU - Hansen, Thomas
AU - Ingason, Andrés
AU - Djurovic, Srdjan
AU - Melle, Ingrid
AU - Fenger, Mogens
AU - Gustafsson, Omar
AU - Jakobsen, Klaus D
AU - Rasmussen, Henrik B
AU - Tosato, Sarah
AU - Rietschel, Marcella
AU - Frank, Josef
AU - Owen, Mike
AU - Bonetto, Chiara
AU - Suvisaari, Jaana
AU - Thygesen, Johan Hilge
AU - Pétursson, Hannes
AU - Lönnqvist, Jouko
AU - Sigurdsson, Engilbert
AU - Giegling, Ina
AU - Craddock, Nick
AU - O'Donovan, Michael C
AU - Ruggeri, Mirella
AU - Cichon, Sven
AU - Ophoff, Roel A
AU - Pietiläinen, Olli
AU - Peltonen, Leena
AU - Nöthen, Markus M
AU - Rujescu, Dan
AU - St Clair, David
AU - Collier, David A
AU - Andreassen, Ole A
AU - Werge, Thomas
N1 - Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
PY - 2011/7/1
Y1 - 2011/7/1
N2 - BACKGROUND: Schizophrenia is associated with increased risk of type II diabetes and metabolic disorders. However, it is unclear whether this comorbidity reflects shared genetic risk factors, at-risk lifestyle, or side effects of antipsychotic medication. METHODS: Eleven known risk variants of type II diabetes were genotyped in patients with schizophrenia in a sample of 410 Danish patients, each matched with two healthy control subjects on sex, birth year, and month. Replication was carried out in a large multinational European sample of 4089 patients with schizophrenia and 17,597 controls (SGENE+) using Mantel-Haenszel test. RESULTS: One type II diabetes at-risk allele located in TCF7L2, rs7903146 [T], was associated with schizophrenia in the discovery sample (p = .0052) and in the replication with an odds ratio of 1.07 (95% confidence interval 1.01-1.14, p = .033). CONCLUSION: The association reported here with a well-known diabetes variant suggests that the observed comorbidity is partially caused by genetic risk variants. This study also demonstrates how genetic studies can successfully examine an epidemiologically derived hypothesis of comorbidity.
AB - BACKGROUND: Schizophrenia is associated with increased risk of type II diabetes and metabolic disorders. However, it is unclear whether this comorbidity reflects shared genetic risk factors, at-risk lifestyle, or side effects of antipsychotic medication. METHODS: Eleven known risk variants of type II diabetes were genotyped in patients with schizophrenia in a sample of 410 Danish patients, each matched with two healthy control subjects on sex, birth year, and month. Replication was carried out in a large multinational European sample of 4089 patients with schizophrenia and 17,597 controls (SGENE+) using Mantel-Haenszel test. RESULTS: One type II diabetes at-risk allele located in TCF7L2, rs7903146 [T], was associated with schizophrenia in the discovery sample (p = .0052) and in the replication with an odds ratio of 1.07 (95% confidence interval 1.01-1.14, p = .033). CONCLUSION: The association reported here with a well-known diabetes variant suggests that the observed comorbidity is partially caused by genetic risk variants. This study also demonstrates how genetic studies can successfully examine an epidemiologically derived hypothesis of comorbidity.
U2 - 10.1016/j.biopsych.2011.01.031
DO - 10.1016/j.biopsych.2011.01.031
M3 - Journal article
C2 - 21414605
VL - 70
SP - 59
EP - 63
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 1
ER -
ID: 34053301